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Why Whole Plant Cannabidiol is Superior for Medical Treatments

\n

Earlier this year, an Israeli study entitled \"Overcoming the Bell-Shaped\nDose-Response of Cannabidiol by Using Cannabis Extract Enriched in\nCannabidiol\"\nwas published in the journal Pharmacology & Pharmacy. This study\nproved that for clinical use, whole plant CBD-rich cannabis extracts and\nproducts are significantly more effective and therapeutic than synthetic\nsingle-molecule CBD. As a result of its findings, this study put to bed\nthe stereotyped notion that \"crude\" CBD compounds are low-quality and\nless effective than their pure, synthetic counterparts.

\n

The findings of this study have major implications for\nphytopharmaceutical and medical marijuana industries and may produce\ntreatments that can help patients cope with painful and difficult\ninflammatory diseases.

\n

What is CBD?

\n

CBD, both whole plant and synthetic varieties, is a compound derived\nfrom cannabis that offers considerable medical\nbenefit\nwithout making patients feel \"high.\" This is because CBD-rich cannabis\nstrains are not psychoactive or are less psychoactive than their\nTHC-dominant counterparts. This makes them effective and appealing\ntreatment options for patients suffering from inflammatory\ndiseases.\npain,\nseizures,\nor\nanxiety.

\n

Many studies have been conducted on the clinical uses of CBD, and\ncurrently, the compound is being evaluated as a treatment option for\neverything from\narthritis,\nmigraines\nand\ndiabetes\nto\nPTSD,\ndepression\nepilepsy\nand chronic\npain.\nAdditionally, CBD has been shown to have considerable\nanti-cancer\nproperties as well as significant neuroprotective and neurogenic\ncapabilities, which may expand its therapeutic uses in the future.

\n

The Israeli Study and the Bell-Shaped Curve

\n

The Israeli study set out to compare the therapeutic benefits of\nCBD-rich cannabis extracts and single-molecule CBD. To begin this\nprocess, the researchers consulted preclinical studies from the last 15\nyears. The team quickly discovered that when single-molecule synthetic\nCBD was administered orally or in injection form to a patient suffering\nfrom a condition like inflammatory bowel disease (IBS), multiple\nsclerosis (MS), diabetes or rheumatoid arthritis, the treatment produced\na bell-shaped curve between dose and response. This means that, after a\ncertain dosage amount, the impact of CBD ceased to be therapeutic. The\ntherapeutic dosage window for synthetic CBD was very limited and there\nwere no positive effects noted in patients when single-molecule CBD was\ngiven in higher or lower doses. This trait of single-molecule CBD limits\nits usefulness and makes it difficult to utilize effectively in a\nclinical setting.

\n

The Clinical Difference Between Whole Plant and Synthetic CBD

\n

After discovering the bell-shaped pattern created by single-molecule\nCBD, the Israeli team set out to learn more about the treatment\ndifferences between single-molecule CBD and whole plant extract rich in\nCBD. To do this, they located a CBD-rich cannabis strain that had very\nlittle THC (this strain was similar to California's ACDC strain, which\nhas long been favored by\ngrowers\nfor its high CBD content) and administered both the whole plant and\nsynthetic varieties to mice. Upon doing this, the researchers confirmed\nthat when single-molecule CBD was administered, it produced a\nbell-shaped curve with a very narrow zone for therapeutic\nadministration. The whole plant CBD extract, however, had a much\ndifferent effect.

\n

Unlike the single-molecule CBD, the whole plant CBD-rich extract\nproduced a direct and immediate reduction in pain, inflammation and\nTNFa production, which is\na protein that plays a significant role in inflammation. These results\nproved that CBD-rich cannabis extract is actually more effective at\nreducing inflammation than commercial painkillers. In fact, when the\nresearchers tested whole plant CBD and aspirin side-by-side, they found\nthat the whole plant CBD-rich extract produced a much more pronounced\nanti-inflammatory effect than aspirin.

\n

Additionally, unlike purified CBD, CBD-rich extract displayed a direct\ncorrelation between dose and effectiveness. Whole plant CBD extract\nexhibited increased therapeutic responses in accordance with increasing\ndoses, which makes this treatment option attractive and applicable to\npatients in a clinical setting. Finally, the researchers discovered that\nthe amount of CBD-rich extract required to produce a therapeutic effect\nin patients was much smaller than the amount of pure CBD required to\nproduce the same therapeutic effect. These finding indicate how CBD-rich\nextract can be used more sparingly in patients suffering from\nuncomfortable conditions.

\n

The Future of Whole Plant CBD

\n

CBD-rich extract has a direct dose-response reaction, low administration\nrequirements and profound anti-inflammatory properties. Using these\nresults, the Israeli researchers determined that CBD-rich extract is\nsuperior to single-molecule CBD for treatment of conditions that involve\ninflammation and pain. Although the exact reason for this increased\neffectiveness requires further study, researchers currently believe it\nmay be due to an interaction between the CBD itself and\nphytocannabinioids and non-cannabinoid compounds. Although further\nclinical trials are required to better understand the treatment\napplications of CBD-rich extract, it is clear that whole plant CBD has\nthe potential to change or compliment the treatment options for many\ncommon conditions that were previously treated by synthetic drugs alone.\nBecause of this, CBD-rich extract gives patients a powerful tool to\nreclaim their well being. In addition to offering a lower dose of\ntreatment than single-molecule CBD, CBD-rich extract also produces fewer\nadverse effects and has the potential to leave patients feeling better,\ndespite their health difficulties and painful conditions.

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