{"componentChunkName":"component---common-build-question-tags-template-js","path":"/question-tag/cbc/","result":{"data":{"allQuestion":{"edges":[{"node":{"id":"Question_12325-markdown","title":"Can I use cbc with xarelto?","slug":"can-i-use-cbc-with-xarelto","content":"\"rfcollins@outlook.com\"\n_____________________\nHi there!\nThe  cytochrome p450 system accounts for 70 to 80 percent of the enzymes involved in drug clearance, making it the most important system for drug  metabolism. Both THC and CBD are competitive inhibitors of three different enzymes in the cytochrome p450 system, two of which  are  involved in the metabolism of Xarelto (rivaroxaban). This means that CBD and THC  are  competing for the same receptors as is Xarelto. So when Xarelto is  taken concurrently with CBD and/or THC, Xarelto levels could possibly rise. When Xarelto levels rise excessively, blood clotting may become compromised, leading to signs ranging from frequent bloody noses, all the way on up to a potentially fatal event, such as a hemorrhagic stroke or heart attack.\nhttps://ghr.nlm.nih.gov/primer/genefamily/cytochromep450\n\nA  case report published in 2009  described a patient who was on coumadin (Warfarin) —the most commonly prescribed blood thinner— therapy for eleven years. He was admitted to the hospital for a severe  gastrointestinal bleed when he confessed to  consuming much more cannabis than was typical for him; his INR was 10.41 (therapeutic range is usually between 2 and 3); after inpatient treatment, his INR normalized; then, fifteen days after being discharged, he was readmitted with an INR of 11.55; after he quit using cannabis, his INR remained between 1.08 and 4.40 and he suffered no further complications.  \nhttps://www.ncbi.nlm.nih.gov/pubmed/19531696\n\ndrkim\n_____________________\nAnother case report suggested that extremely high doses of CBD can  lead  to markedly elevated coumadin levels. Enrolled in a clinical trial evaluating CBD as a potential treatment for epilepsy, the test subject was given extremely high doses of CBD. He was first given doses averaging 265mg, which resulted in a slightly elevated coumadin level;  at doses averaging 528mg, the coumadin levels were markedly elevated;  after reducing the coumadin dose, INR results normalized. Relevantly, very few patients, if any, would ever take as much CBD.\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789126/\n\nHowever, as previously mentioned, a highly elevated Xarelto level can lead to serious, even fatal, consequences. And because the effects of cannabis on Xarelto levels have yet to be sufficiently studied, you  should discuss the matter with your prescribing physician and monitor your INR results with extra vigilance.\n\ndrkim\n_____________________\nYou're very welcome Colly. CBD and Xarelto would still compete for the same p450 isoenzymes. However, because CBD has low affinity to those isoenzyes, it would take much more than 40mg to affect coagulation. Your anesthesiologist will make sure coagulation isn't compromised with a blood test prior to surgery. Best of luck!\n\ndrkim","image":null}},{"node":{"id":"Question_9475-markdown","title":"A dosing question about CDB / THC Isolate Hemp Oil. 150mg, 1 to 1 ratio.","slug":"a-dosing-question-about-cdb-thc-isolate-hemp-oil-150mg-1-to-1-ratio","content":"","image":null}},{"node":{"id":"Question_9163-markdown","title":"Does alcohol in extract change the property of THC or CDB?","slug":"does-alcohol-in-extract-change-the-property-of-thc-or-cdb","content":"\n_____________________\nAlcohol in extract can pull out more of the cannabis plant compounds like cannabinoids, terpenoids, flavinoids etc.., it should not change the THC or CBD properties. Alcohol is also a great preservative, with some tinctures lasting 4-5 years. It also permeates the mucus membranes in the mouth to enter the bloodstream more quickly.\n\nPiantaTinta","image":null}},{"node":{"id":"Question_7305-markdown","title":"I have brain cancer would cdb help with my headaches and nerve pains","slug":"i-have-brain-cancer-would-cdb-help-with-my-headaches-and-nerve-pains","content":"\n_____________________\nYes cannabis can help with brain cancer, headaches and nerve pains. The cannabinoids (CBD, THC, CBN, CBG and many others) work best when they are utilized in a whole plant preparation. Isolated cannabinoids are far less effective, as the cannabinoids work together in a synergystic fashion. I would try a sublingual tincture of whole plant cannabis extract with CBD, THC and the other components found in cannabis. You can vary the ratio and see what works best for you and your lifestyle. With more THC you may find more pain relief, but you may experience more psychoactive effects, changes in perception and short term memory. When utilizing the tincture, allow it to absorb in your mouth, so that it goes directly into your bloodstream. Try a small dose (5-10 milligrams of cannabinoids), and wait for half an hour to see if you experience relief. Increase the dose as needed. Vaporizing cannabis will provide more immediate relief and is often a bit easier to titrate the appropriate dose. You may also try topical cannabis rubs or a transdermal patch applied to the most painful area.\n\nandrewvanmd","image":null}},{"node":{"id":"Question_6621-markdown","title":"Why is CDB extracted from Cannabis better than from Hemp","slug":"why-is-cdb-extracted-from-cannabis-better-than-from-hemp","content":"\n_____________________\nThis is a very common question. I checked the projectcbd.org page and here is what they said about CBD extracted from industrial hemp:\n\nCBD products derived from industrial hemp potentially have several problems:\n\n1. Industrial hemp typically contains far less cannabidiol than CBD-rich cannabis strains so a huge amount of industrial hemp is required to extract a small amount of CBD. This raises the risk of contaminants as hemp is a “bio-accumulator”—meaning the plant naturally drawns toxins from the soil.\n2. Hemp-derived CBD and refined CBD powder lack critical medicinal terpenes and secondary cannabinoids found in cannabis oil. These compounds interact with CBD and THC to enhance their medicinal benefits.\n3. It’s against federal law to use hemp leaves and flowers to make drug products. Hemp oil entrepreneurs attempt to sidestep this legal hurdle by dubiously claiming they extract CBD only from hemp stalk before importing it to the United States, a grey area activity at best.\n\nPiantaTinta","image":null}},{"node":{"id":"Question_11229-markdown","title":"will cdb help parkenson disorder such as severe tremors","slug":"will-cdb-help-parkenson-disorder-such-as-severe-tremors","content":"\"I am a 69 year young combat Marine veteran of VietNam rated at 250% disability,  weigh 280lbs down from 332 six months ago through lifestyle change (diet and exercise)I refuse to take l-dopa/ dopimine or other drugs the VA is pushing. Need help for tremors. \"\n_____________________\nI have a friend who is 74. She was diagnosed with Parkinson's when she was 68. She takes a marijuana oil every day which keeps her going she says, it gives her energy. She has very mild tremors. I don't know if she ever had severe tremors. May your symptoms be alleviated. Blessings.\n\nbhavana","image":null}}]}},"pageContext":{"limit":12,"skip":0,"numPages":1,"currentPage":1,"id":5083,"name":"Cbc","slug":"cbc","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}