{"componentChunkName":"component---common-build-question-tags-template-js","path":"/question-tag/cbd/3","result":{"data":{"allQuestion":{"edges":[{"node":{"id":"Question_12338-markdown","title":"Best CBD product for stress and anxiety?","slug":"best-cbd-product-for-stress-and-anxiety","content":"\"@\"\n_____________________\n \nHi there! \nRestoring  activity in serotonin  pathways—by increasing the serotonin available  to bind the 5-HT1A receptor in the brain—is how SSRIs  (Selective   Serotonin Reuptake Inhibitors) are thought to alleviate anxiety and    depression. Similarly, several recently published studies suggest  that  CBD does the same. However, CBD does so, not by increasing the   serotonin available to bind 5-HT1A receptors, as SSRIs do, but by   mimicking serotonin's action at the 5-HT1A receptor; or, in scientific   terms: CBD is a 5-HT1A  receptor agonist. \nhttps://www.ncbi.nlm.nih.gov/pubmed/16258853\nhttps://www.ncbi.nlm.nih.gov/pubmed/24923339\n\n\ndrkim\n_____________________\nWhen looking for a quality CBD oil, pill or vape cartridge, make sure that they:\n1. Use CO2 extraction\n2. Practice \"Whole plant philosophy\", which should preserve many of the lesser known cannabinoids, terpenes, and flavonoids found in cannabis.  \n3. Use organic  hemp or cannabis \n4.  Clearly labeled bottle, specifying the milligrams of CBD per dose—skip  it if it only indicates the total amount of CBD in the product.\n\nProducts that checks off all the boxes: \nOils\nhttps://www.hellolift.com/products/5b57ae8402f1740001523015/cbd-reliefhttps://www.hellolift.com/products/5b57b4c702f1740001523089/cured-full-spectrum-raw-oilhttps://www.hellolift.com/products/5b57a95202f1740001522f9f/cbd-hemp-oil-drops\n\nCapsules\nhttps://www.hellomd.com/products/5b57a71f02f1740001522f78/cbd-hemp-oil-capsules\n\nVaproizers\n https://www.hellolift.com/products/5b5770d702f1740001522c60/cbd-aches \nhttps://www.hellolift.com/products/5b985b85d4b1b9f913c11e51/cbd-hemp-vape-cartridge\n\nI hope this helps!\n\n\n\n\ndrkim","image":null}},{"node":{"id":"Question_12331-markdown","title":"Are there any CBD products that are legal for international travel?","slug":"are-there-any-cbd-products-that-are-legal-for-international-travel","content":"\"London, Nairobi, Ethiopia, Thailand, Vietnam, Laos, Cambodia, and China. \"\n_____________________\nIn general, it is not recommended that you travel internationally with a potentially illegal substance. Even though CBD oil may be legal at your point of departure, you will be responsible for obeying local laws when you land. Even flying within the US is a grey area: CBD may be legal where you take off and land, but when you are in the air, you are governed by federal law - and CBD is still  considered a controlled substance on a federal level.\n\nKevin P.","image":null}},{"node":{"id":"Question_12330-markdown","title":"Does CBD help with spinal stenosis?","slug":"does-cbd-help-with-spinal-stenosis","content":"\"Asking for a friend.\"\n_____________________\nHi there!\nAs a part  of normal aging, the spine can develop arthritis. As the arthritis  progresses, bone spurs form and enlarge, and the ligaments around the  joints thicken to a point when the spinal canal narrows enough to  compress the nerves—which leads to neuropathic pain. \n\nWhile arthritis and stenosis cause different types of pain, CBD should help alleviate both types. Arthritis causes nociceptive pain, whereas spinal stenosis eventually leads to neuropathic pain. \n\nNociceptors are pain receptors that detect when there is a threat to  your body, which then tell your brain to respond to the threat. NSAIDs  and opiates work well at treating this type of pain, because they  interrupt the transmission of pain signals traveling from the site of injury to your brain. \n\nNeuropathic pain, on the other hand, is due to damage to  the nerve itself, which causes pain signals to continually fire, even  if there is no injury elsewhere. Neuropathic pain is often  described as  a tingling, burning or electric feeling. If you suffer from neuropathic pain,  then I'm sure you're well aware that this form of pain is  extremely difficult to treat.\n\n\ndrkim\n_____________________\nSeveral studies suggest that cannabis can help alleviate the pain of  arthritis (nociceptive pain). And while cannabis research has  historically focused on THC, synthetic cannabinoids, or our own  naturally occurring cannabinoids (endocannabinoids), there is an  evergrowing body of research regarding the potential medicinal benefits of CBD. In fact, a recently published study concluded that \"topical CBD application has therapeutic potential for relief of arthritis pain and  inflammation\"\nhttps://mg.mail.yahoo.com/d/compose/7963612517\n\nIn  a study with exciting implications, researchers concluded that \"CBD,  through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect\" which may even \"block the  progression of arthritis.\"\nhttps://www.ncbi.nlm.nih.gov/pubmed/10920191\n\nIn a study published in the British Journal of Pharmacology, researchers found that chronic administration of CBD prevented paclitaxel-induced neuropathy (PAC) (paclitaxel is a common chemotherapy agent which often  causes neuropathic pain). Interestingly, they found that the cannabinoid  receptors CB1 and CB2 were not involved in preventing the pain from developing. Rather, they concluded that CBD is protective against PAC-induced neurotoxicity mediated in part by the serotonin receptor  system. Modulation of the serotonin receptor system is also the method  that antidepressant drugs are thought to affect neuropathic pain.\n https://www.ncbi.nlm.nih.gov/pubmed/24117398\n\n\ndrkim\n_____________________\nFurthermore, there are also several pre-clinical studies showing  that CBD is effective at treating both inflammatory (nociceptive) and  neuropathic pain. Again, researchers determined that the CB1 and CB2  receptors were not involved in the neuropathic pain relief. Instead,  they determined that the pain relief was derived from CBD's ability to modulate the TRPV1 receptor—the same receptor responsible for  transmitting pain from contact with pepper spray and eating chili  peppers. \nhttps://www.ncbi.nlm.nih.gov/pubmed/15313881\n\nCannabidiol's activity was also associated with a reduction in the content of  several  inflammatory mediators, including prostaglandin E(2) (PGE(2)), lipid peroxide  and nitric oxide (NO), and in the over-activity of glutathione-related  enzymes. \nhttps://www.ncbi.nlm.nih.gov/pubmed/17157290\n\nThere is also a significant amount of research showing that Sativex -- an  oromucosal spray with 1CBD:1THC -- effectively reduces neuropathic pain.  In 2005, Sativex was approved in Canada for the treatment of central  neuropathic pain in multiple sclerosis, and in 2007 for intractable  cancer pain. Numerous randomized clinical trials have demonstrated  safety and efficacy for Sativex in central and peripheral neuropathic  pain, rheumatoid arthritis and cancer pain.\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/ \n\nI hope this helps!\n\n\ndrkim","image":null}},{"node":{"id":"Question_12329-markdown","title":"Does CBD help with spinal stenosis?","slug":"does-cbd-help-with-spinal-stenosis-1","content":"\"Asking for a friend.\"\n_____________________\nHi there!\nAs a part  of normal aging, the spine can develop  arthritis. As the arthritis  progresses, bone spurs form and enlarge,  and the ligaments around the  joints thicken to a point when the spinal  canal narrows enough to  compress the nerves—which leads to neuropathic  pain.\n\nWhile arthritis and stenosis cause different types of pain,  CBD should help alleviate both types. Arthritis causes nociceptive  pain, whereas spinal stenosis eventually leads to neuropathic pain.\n\nNociceptors  are pain receptors that detect when there is a threat to  your body,  which then tell your brain to respond to the threat. NSAIDs  and opiates  work well at treating this type of pain, because they  interrupt the  transmission of pain signals from the site of injury to  your brain.\n\nNeuropathic  pain, on the other hand, is due to damage to  the nerve itself, which  causes pain signals to continually fire, even  if there is no injury  elsewhere. Neuropathic pain is often  described as  a tingling, burning  or electric feeling. If you suffer from neuropathic pain,  then I'm sure  you're well aware that this form of pain is  extremely difficult to  treat.\n\ndrkim\n_____________________\nSeveral studies suggest that cannabis can help alleviate the pain of   arthritis (nociceptive pain). And while cannabis research has   historically focused on THC, synthetic cannabinoids, or our own   naturally occurring cannabinoids (endocannabinoids), there is an   evergrowing body of research regarding the potential medicinal benefits  of CBD. In fact, a recently published study concluded that \"topical CBD  application has therapeutic potential for relief of arthritis pain and   inflammation\"\nhttps://mg.mail.yahoo.com/d/compose/7963612517\n\nIn   a study with exciting implications, researchers concluded that \"CBD,   through its combined immunosuppressive and anti-inflammatory actions,  has a potent anti-arthritic effect\" which may even \"block the   progression of arthritis.\"\nhttps://www.ncbi.nlm.nih.gov/pubmed/10920191\n\nIn  a study published in the British Journal of Pharmacology, researchers  found that chronic administration of CBD prevented paclitaxel-induced  neuropathy (PAC) (paclitaxel is a common chemotherapy agent which often   causes neuropathic pain). Interestingly, they found that the  cannabinoid  receptors CB1 and CB2 were not involved in preventing the  pain from developing. Rather, they concluded that CBD is protective  against PAC-induced neurotoxicity mediated in part by the serotonin  receptor  system. Modulation of the serotonin receptor system is also  the method  that antidepressant drugs are thought to affect neuropathic  pain.\n https://www.ncbi.nlm.nih.gov/pubmed/24117398\n\ndrkim\n_____________________\nFurthermore, there are also several pre-clinical studies showing  that  CBD is effective at treating both inflammatory (nociceptive) and   neuropathic pain. Again, researchers determined that the CB1 and CB2   receptors were not involved in the neuropathic pain relief. Instead,   they determined that the pain relief was derived from CBD's ability to  modulate the TRPV1 receptor—the same receptor responsible for   transmitting pain from contact with pepper spray and eating chili   peppers. \nhttps://www.ncbi.nlm.nih.gov/pubmed/15313881\n\nCannabidiol's  activity was also associated with a reduction in the content of   several  inflammatory mediators, including prostaglandin E(2) (PGE(2)),  lipid peroxide  and nitric oxide (NO), and in the over-activity of  glutathione-related  enzymes. \nhttps://www.ncbi.nlm.nih.gov/pubmed/17157290\n\nThere  is also a significant amount of research showing that Sativex -- an   oromucosal spray with 1CBD:1THC -- effectively reduces neuropathic pain.   In 2005, Sativex was approved in Canada for the treatment of central   neuropathic pain in multiple sclerosis, and in 2007 for intractable   cancer pain. Numerous randomized clinical trials have demonstrated   safety and efficacy for Sativex in central and peripheral neuropathic   pain, rheumatoid arthritis and cancer pain.\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/\n\nI hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_12328-markdown","title":"Does cbd help spinal stenosis?  ","slug":"does-cbd-help-spinal-stenosis","content":"\"And any suggestions on what to get if so im thinking cream or edibles. Thank you for your help.\"\n_____________________\nAs you may know spinal stenosis is a condition that can be very debilitating and we typically want to avoid any invasive treatments such as surgery, if possible.  The mainstay of treatment is to try and relieve pain which can be done with physiotherapy, NSAIDS, neuropathic agents, opioids, etc... Cannabis can be a very helpful adjunct to therapy or even allow someone who is using opioids for pain control, to possible reduce or discontinue use.  CBD has been shown to assist in reducing inflammation as well as help with muscle spasms.  In any case, it may be a helpful resource for assisting in the pain associated with spinal stenosis.\n\nAmyT","image":null}},{"node":{"id":"Question_12320-markdown","title":"Struggling with side effects","slug":"struggling-with-side-effects","content":"\"I was instructed by my psychiatrist to start CBD oil on top of my Cymbalta because I can’t tolerate going up anymore on the dosage. First weeks of using CBD from reparable brands I felt great. Lifted my mood, gave me energy, could take multiple dosages of it a day and felt fine. But now it’s making me really sleepy, even at low dosages, I’m talking about less than 5 mg here. I take it sublingually. It’s full spectrum CBD too. If I stop taking it, the low mood will start coming back, so it is working for that but the triedness is becoming a problem. It was working so good that I felt like I’d be able to reduce my antidepressant one day. Now I feel I can’t tolerate the CBD oil. Btw, if I take it at night, I either have where I’m tired the next day or sometimes (and this is the weirdest thing) it’ll wake me up. Still is all very frustrating. \"\n_____________________\nHi there! I think it would be a great idea to discuss your experience, and tapering off of the Cymbalta, with your psychiatrist.  I would also be glad more than glad to help. But, in the meantime, it would be best to reserve the CBD for the evening, and/or reduce the dosage amount and frequency. I hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_12316-markdown","title":"Can CBD help with GI issues? ","slug":"can-cbd-help-with-gi-issues","content":"\"Specifically IBS, IBD, and GERD?\"\n_____________________\nHi there!\n\nThe endocannabinoid system (ECS) is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium). Deficiency or malfunction of the ECS has become a focus for researchers seeking treatment options for several maladies—especially those that have few, if any, effective pharmocotherapeutic interventions, such as celiac disease, MS, fibromyalgia, IBD and IBS. In fact, the scientific community has recently termed the ECS malfunction: Clinical Endocannabanoid Decifiency, or CEDC. CBD works by balancing and supporting the ECS through its subtle effects on cannaboinoid receptor-1 (CB1) and cannaboinoid receptor-2 (CB2) receptors, as well as other receptors that modulate serotonin, GABA, dopamine, and many more.\nIn IBD and GERD, inflammation is central to both the etiology and symptomology of the respective disease. CBD is well known as an effective immunomodulator and anti-inflammatory, and those properties still do apply to GI inflammation. However, unique to the GI tract, are specialized nerve cells called enteric glial cells— \"the glue of the nteric nervous system (ENS)\"—which, when overactive, also contribute to acute and chronic GI inflammation. Recent pre-clinical research suggests that CBD may lower GI inflammation by controlling reactive gliosis in the ENS. Or, in other words, CBD restores homeostasis in the gut by reducing hyperactivity in enteric glial cells.\n\ndrkim\n_____________________\nThe ENS is an extensive network of neurons supported by enteric glial cells (the above mentioned \"glue\" on the ENS). Two neural plexuses comprise the ENS: the myenteric plexus, involved in motility/peristalsis; and the submucosal plexus, involved in intestinal and gastric secretions. CBD works to restores homeostasis in the ENS via modulation of enteric glial cells (as mentioned above), the myenteric plexus, and the submucosal plexus.\n\nAlthough inflammation plays little, if any, role in the pathology of IBS, CBD's balancing of the myenteric plexus lessens inappropriate and painful intestinal contractions; while balancing of the submucosal plexus reduces inappropriate gastric and intestinal secretions. CBD's effects on glial cells, the submucosal plexus and myenteric plexus factor into CBD's ability to alleviate symptoms of GERD, IBS and IBD.\n\nAn ongoing, randomized, placebo controlled, double-blind, cross-over trial has shown chewable CBD to significantly reduce IBS-related pain. To be included in the study, it was also necessary that patients experienced, according to their own account, at least three pain episodes per week of a predefined intensity. All patients who participated in the study experienced decrease in their levels of pain score. On top of the overall reduction, the trend curve suggests 50% higher pain reduction.\n\ndrkim\n_____________________\nFurthermore, several studies show that among patients who seek medical attention for IBS or IBD, around 70% of IBS patients, and 30% of IBD patients, have psychiatric comorbidity—depression and generalized anxiety disorder being most common. CBD increases serotonin signaling at the 5-HT1A receptor—the same neurotransmitter and receptor that SSRIs like Prozac influence—which is mostly why CBD has antidepressant and anxiolytic properties. In fact, SSRIs and tricyclic antidepressants (which also increase serotonin signalling), have been shown to alleviate anxiety and depression symptoms, as well as alleviate some of the abdominal pain and bowel symptoms involved in IBS, IBD and gastroesophageal reflux disease (GERD), which is why SSRIs and TCAs are commonly prescribed for IBS and IBD.\n\nI hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_12315-markdown","title":"Can CBD help with GI issues?","slug":"can-cbd-help-with-gi-issues-1","content":"\"Like IBS, IBD and GERD?\"\n_____________________\nHi there!\nThe endocannabinoid system (ECS) is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium). Deficiency or malfunction of the ECS has become a focus for researchers seeking treatment options for several maladies—especially those that have few, if any, effective pharmocotherapeutic interventions, such as celiac disease, MS, fibromyalgia, IBD and IBS. In fact, the scientific community has recently termed the ECS malfunction: Clinical Endocannabanoid Decifiency, or CEDC. CBD works by balancing and supporting the ECS through its subtle effects on cannaboinoid receptor-1 (CB1) and cannaboinoid receptor-2 (CB2) receptors, as well as other receptors that modulate serotonin, GABA, dopamine, and many more.\n\nIn IBD and GERD, inflammation is central to both the etiology and symptomology of the respective disease. CBD is well known as an effective immunomodulator and anti-inflammatory, and those properties still do apply to GI inflammation. However, unique to the GI tract, are specialized nerve cells called enteric glial cells— \"the glue of the enteric nervous system (ENS)\"—which, when overactive, also contribute to acute and chronic GI inflammation. Recent pre-clinical research suggests that CBD may lower GI inflammation by controlling reactive gliosis in the ENS. Or, in other words, CBD restores homeostasis in the gut by reducing hyperactivity in enteric glial cells.\n\ndrkim\n_____________________\nThe enteric ENS is an extensive network of neurons supported by enteric glial cells (the above mentioned \"glue\" on the ENS). Two neural plexuses comprise the ENS: the myenteric plexus, involved in motility/peristalsis; and the submucosal plexus, involved in intestinal and gastric secretions. CBD works to restores homeostasis in the ENS via modulation of enteric glial cells (as mentioned above), the myenteric plexus, and the submucosal plexus.\n\nAlthough inflammation plays little, if any, role in the pathology of IBS, CBD's balancing of the myenteric plexus lessens inappropriate and painful intestinal contractions; while balancing of the submucosal plexus reduces inappropriate gastric and intestinal secretions. CBD's effects on glial cells, the submucosal plexus and myenteric plexus factor into CBD's ability to alleviate symptoms of GERD, IBS and IBD.\n\nAn ongoing, randomized, placebo controlled, double-blind, cross-over trial has shown chewable CBD to significantly reduce IBS-related pain. To be included in the study, it was also necessary that patients experienced, according to their own account, at least three pain episodes per week of a predefined intensity. All patients who participated in the study experienced decrease in their levels of pain score. On top of the overall reduction, the trend curve suggests 50% higher pain reduction.\n\ndrkim\n_____________________\nFurthermore, several studies show that among patients who seek medical attention for IBS or IBD, around 70% of IBS patients, and 30% of IBD patients, have psychiatric comorbidity—depression and generalized anxiety disorder being most common. CBD increases serotonin signaling at the 5-HT1A receptor—the same neurotransmitter and receptor that SSRIs like Prozac influence—which is mostly why CBD has antidepressant and anxiolytic properties. In fact, SSRIs and tricyclic antidepressants (which also increase serotonin signalling), have been shown to alleviate anxiety and depression symptoms, as well as alleviate some of the abdominal pain and bowel symptoms involved in IBS, IBD and gastroesophageal reflux disease (GERD), which is why SSRIs and TCAs are commonly prescribed for IBS and IBD.\n\nI hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_12312-markdown","title":"what is best for severe insomnia?","slug":"what-is-best-for-severe-insomnia","content":"\"I have gotten other CBD but I relied on the drivers and have no idea what I got..please help.\"\n_____________________\nThe answer depends on whether you have difficulty falling asleep or staying asleep. If the former, you may want something fast-acting like a tincture or vaporizer to help you get to sleep right away. On the other hand, a CBD edible's effects can last for several hours - perfect for helping you sleep through the night.\n\nWe have a great article here, \"4 Ways You Can Use CBD To Beat Insomnia\", with some other great tips and advice: https://www.hellolift.com/health-wellness/5be3805026ef630008f055c5/4-ways-you-can-use-cbd-to-beat-insomnia\n\nKevin P.","image":null}},{"node":{"id":"Question_12309-markdown","title":"What cbd product might i take for seizures","slug":"what-cbd-product-might-i-take-for-seizures","content":"\"Have been diagnosed with seizure activity that is mild (absentee seizures). I take Keppra for this. My doctor here in Arkansas said I could also take some cbd product to help. Since cbd is new to Arkansas my Dr. had no advice as to dosage or brand of cbd product. His advice was basically to experiment like it was a dietary supplement from WALMART. Do you have any information that might help me find out what cbd product might be good for me?\"\n_____________________\nHello and thank you for your question,\nCannabis is now very well  known for it's efficacy as an anti-epileptic medication. In fact, the  walk in clinic I also work at receives several referrals from the  neighboring Children's Hospital for their seizure patients; I myself  have treated patients as young as three.\n\nThe story that really  put cannabis in the spotlight as an effective anti-epilectic was the  story of Charlotte Figi, a beautiful child who was suffering from up to  300 grand mal seizure per week! She was eventually treated with a cbd  oil which reduced her seizure frequency down to two to three times per  month; that's about a 99% improvement! That cbd oil that was eventually  branded as Charlotte's Web.\n\nTherefore, I would recommend a cbd  oil to ingest as daily prevention while also carrying a pen vaporizer  loaded with a cbd cartridge to use if you experience an aura - i.e. a sensory warning that a seizure is about to occur. I recommend a vape pen  in the above scenario since a vape pen is the quickest delivery method  available. Therefore, when/if you experience an aura, you could  hopefully get a dose in before the seizure starts.\n\ndrkim\n_____________________\nExcellent CBD oils:\nhttps://www.hellolift.com/products/5b57a95202f1740001522f9f/cbd-hemp-oil-drops\nhttps://www.hellolift.com/products/5b57b4c702f1740001523089/cured-full-spectrum-raw-oil\nExcellent CBD vapes:\nhttps://www.hellolift.com/products/5bb53ed015dd427039a0a351/relax-vape-pen\nhttps://www.hellolift.com/products/5b5770d702f1740001522c60/cbd-aches\nI hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_12308-markdown","title":"Can CBD help manage Irritable Bowel Syndrome (IBS)?","slug":"can-cbd-help-manage-irritable-bowel-syndrome-ibs","content":"\"Thank you!\"\n_____________________\nHi there!\nYes it can. It all boils to the endocannabinoid system  (ECS). The ECS is largely devoted to maintaining homeostasis (the  tendency of organisms to auto-regulate and maintain their internal  environment at equilibrium). Deficiency or malfunction of the ECS has  become a focus for researchers seeking treatment options for several  maladies—especially those that have few, if any, effective  pharmocotherapeutic interventions, such as celiac disease, MS,  fibromyalgia, IBD and IBS. In fact, the scientific community has  recently termed the ECS malfunction: Clinical Endocannabanoid  Decifiency, or CEDC.\n\nCBD works by balancing and supporting the  ECS through its subtle effects on cannaboinoid receptor-1 (CB1) and  cannaboinoid receptor-2 (CB2) receptors, as well as other receptors that  modulate serotonin, GABA, dopamine, and many more.\n\nIn IBS, IBD  and GERD, like most every physical-chronic condition, inflammation is  central to both the etiology and symptomology of the respective disease.  CBD works to reduce inflammation by restoring balance to the ECS.\n\ndrkim\n_____________________\nThe main culprit for acute and chronic inflammation in the gut is  hyperactive enteric glial cells, which proliferate and release  neurotrophins, growth factors, and pro-inflammatory cytokines that may  overamplify the immune response. Recent pre-clinical research suggests  that CBD may lower GI inflammation by controlling reactive gliosis in  the enteric (GI) nervous system. Or, in other words, CBD restores  homeostasis in the gut by reducing hyperactivity in enteric glial cells.\n\nFurthermore,  several studies show that among patients who seek medical attention for  IBS or IBD, around 70% of IBS patients, and 30% of IBD patients, have  psychiatric comorbidity—depression and generalized anxiety disorder  being most common. CBD increases serotonin signaling at the 5-HT1A  receptor—the same neurotransmitter and receptor that SSRIs like Prozac  influence—which is mostly why CBD has antidepressant and anxiolytic  properties. In fact, SSRIs and tricyclic antidepressants (which also  increase serotonin signalling), have been shown to alleviate anxiety and  depression symptoms, as well as alleviate some of the abdominal pain  and bowel symptoms involved in IBS, IBD and gastroesophageal reflux  disease (GERD), which is why SSRIs and TCAs are commonly prescribed for  IBS and IBD.\n\nI hope this helps!\n\ndrkim","image":null}},{"node":{"id":"Question_12307-markdown","title":"Can CBD help with Irritable Bowel Syndrome (IBS)?","slug":"can-cbd-help-with-irritable-bowel-syndrome-ibs","content":"\"Thank you!\"\n_____________________\nHi there!\n\nYes it can. It all boils to the endocannabinoid system (ECS). The ECS is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium). Deficiency or malfunction of the ECS has become a focus for researchers seeking treatment options for several maladies—especially those that have few, if any, effective pharmocotherapeutic interventions, such as celiac disease, MS, fibromyalgia, IBD and IBS. In fact, the scientific community has recently termed the ECS malfunction: Clinical Endocannabanoid Decifiency, or CEDC. \n\nCBD works by balancing and supporting the ECS through its subtle effects on cannaboinoid receptor-1 (CB1) and cannaboinoid receptor-2 (CB2) receptors, as well as other receptors that modulate serotonin, GABA, dopamine, and many more. \n\nIn IBS, IBD and GERD, like most every physical-chronic condition, inflammation is central to both the etiology and symptomology of the respective disease. CBD works to reduce inflammation by restoring balance to the ECS. \n\ndrkim\n_____________________\nThe main culprit for acute and chronic inflammation in the gut is hyperactive enteric glial cells, which proliferate and release neurotrophins, growth factors, and pro-inflammatory cytokines that may overamplify the immune response. Recent pre-clinical research suggests that CBD may lower GI inflammation by controlling reactive gliosis in the enteric (GI) nervous system. Or, in other words, CBD restores homeostasis in the gut by reducing hyperactivity in enteric glial cells. \n\nFurthermore, several studies show that among patients who seek medical attention for IBS or IBD, around 70% of IBS patients, and 30% of IBD patients, have psychiatric comorbidity—depression and generalized anxiety disorder being most common. CBD increases serotonin signaling at the 5-HT1A receptor—the same neurotransmitter and receptor that SSRIs like Prozac influence—which is mostly why CBD has antidepressant and anxiolytic properties. In fact, SSRIs and tricyclic antidepressants (which also increase serotonin signalling), have been shown to alleviate anxiety and depression symptoms, as well as alleviate some of the abdominal pain and bowel symptoms involved in IBS, IBD and gastroesophageal reflux disease (GERD), which is why SSRIs and TCAs are commonly prescribed for IBS and IBD.\n\nI hope this helps!\n\ndrkim","image":null}}]}},"pageContext":{"limit":12,"skip":24,"numPages":66,"currentPage":3,"id":5084,"name":"CBD","slug":"cbd","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}