{"componentChunkName":"component---common-build-question-tags-template-js","path":"/question-tag/dosage/15","result":{"data":{"allQuestion":{"edges":[{"node":{"id":"Question_10818-markdown","title":"Is there a difference with the THC amount when its a suppository? ","slug":"is-there-a-difference-with-the-thc-amount-when-its-a-suppository","content":"\"I am sensitive to THC, so not sure that 60mg of THC would be a good idea. That's the single dosage of this Foria product. I read about it in the news. Any further info on this would be appreciated.\"\n_____________________\nCannabis suppositories may be available in different dosing strengths. It is important to remember that the bioavailability of the drug is much higher when administered rectally (50-60% than when inhaled or taken orally (10-25%). So, the same dose taken rectally will effectively be 4 times stronger. Peak blood plasma levels occur later and are also maintained longer (1-8 hours) as compared to inhalation (3 min - 2 hours) or oral administration (2-4 hours).\n\ndredmunds","image":null}},{"node":{"id":"Question_10813-markdown","title":"How many milligrams of THC are in a typical joint?","slug":"how-many-milligrams-of-thc-are-in-a-typical-joint","content":"**I usually smoke joints and I am fine with that. But if I were to start taking edibles instead, what would be a similar dose?**\n\nMallory\n_____________________\nThe thing to remember is that THC content can vary a lot between strains. Even with edibles many people are unclear about how much THC they are actually consuming. And the psychoactive or “high” depends as much or more on the [heat from vaping or burning](https://www.latimes.com/projects/la-me-weed-101-thc-calculator/) for activating the effects of the compounds than just what’s in the raw cannabis.\n\n![Screen Shot 2021-10-18 at 3.00.36 PM.png](https://hellomd-cms.s3.us-west-2.amazonaws.com/Screen_Shot_2021_10_18_at_3_00_36_PM_3ddaf252ce.png)\nJetty Extracts  prerolls pack a punch!\n\nComparing the amounts of THC in a joint v\nersus an edible is like comparing apples to oranges (or gummies to smoke), because the body metabolizes it in different ways. When smoking a joint, the THC enters the bloodstream quickly after being inhaled in the lungs, so its effects hit faster and die sooner. \n\nWith edibles, the cannabis is sent through the digestive system and metabolized by the liver. So onset of effects can be longer — 30 minutes to two hours typically — and the effects can also last longer than smoking or vaping.  During this process, the liver changes the THC into 11-hydroxy-THC, which can cause a more intense high than THC consumed by smoking.\n\nEdibles can also be more [unpredictable when it comes to dosing](https://hellomd.com/articles/marijuana-edibles-vs-flowers). Ingestion usually delivers only between 10 and 20% of the THC in the product, while smoking delivers a more potent dosage, usually between 50 and 60% of the THC in the flower. Also ingredient labels can sometimes underreport the amount of THC in the edible.\n\nWith an edible, 5mg for me is enough to make me feel stoned and want to go to sleep. For others, this low dosage may not be felt at all. Other people may be able to consume up to 100mg of THC per day and still function. It really depends on your system.\n\nIn terms of smoking, again this is variable. I am unable to smoke typical strains of THC which may be at 18% THC whereas my partner can smoke a whole joint and be functional. So you may have to be careful around [high-THC strains]( https://hellomd.com/articles/top-8-most-potent-high-thc-marijuana-strains). \n\nThe best way to determine what is right for you is to always go low and slow. Start at a bare minimum dosage and wait to feel the effect. Then go from there.\n\nI hope this helps!\n\nPaula T.\n\n-------------\n\n\nIf you roll your own, you can calculate the quantity of THC based on the amount of cannabis you are putting in the joint and the concentration of THC known to be in the strain you are using.\n\nIf you are referring to the average dispensary pre-roll, you are talking about 750mg - 1g of cannabis per joint. The average THC concentration in today's strains is around 12%, which is about 3-4 times as potent as strains a couple decades ago. Using these numbers, this means that your typical pre-roll will have approximately 100mg of THC. Some strains have a THC concentration upwards of 25%.\n\nThe bottom line is, a lot! Caution is advised, and many patients will use one joint over several days for this reason.\n\nIn general, I discourage smoking, because marijuana smoke contains carbon monoxide, tar, carcinogens and other chemicals which may be toxic and damaging to body tissues. Vaporizing shredded flower or CO2-extracted oil concentrates are considered safe alternatives, as we are not aware of any damaging substances in marijuana itself. Vaporizers control the temperature of your medicine such that it only turns into vapor, akin to water turning into steam; and they do not burn the cannabis. Therefore, no smoke with its potentially harmful products of combustion is created.\n\nDr. Edmunds\n\n-----------------------\n\nThe answer to this would be zero. \n\nA typical joint is rolled with cannabis that would typically not have any CBD bred into the strain, or so little it would not register. Most strains today stand between 15%-25% THC. You can of course seek out higher CBD strains such as Harlequin, Cannatonic or Electra Tsu which have a 3:1 ratio (around there) of CBD to THC. You could also seek out a CBD strain such as Charlotte's Web or ACDC which is almost all CBD and has no psychoactive effect.\n\nI am not a doctor and this represents my views. I hope this helps!\n\nPamela Hadfield\n_____________________\nYour typical flower will have between 12%-28% THC and 1%-5% CBD. This works out to 120mg-280mg of THC and 10mg-40mg of CBD. Obivously, all joints are different unless you source them from a reputable and legal collective, or are making them yourself and are meticulous about how much flower you put in each one. Generally speaking, your typical joint will have around .75g of flower which means you're looking at 90mg-210mg of THC and 7.5mg-30mg of CBD per joint. Again, these are estimates because all flowers and all joints are different. If you are in the market for high quality, organic prerolls look no further than Green Door West for a consistent  experience. You can find our 100% organic and vegan menu, which include our prerolls, some of which are made with high-cbd strain like \"Harlequin\" here: https://greendoorwest.com/collections\n\ngreendoorwest\n_____________________\nIt depends on the person. 50 mg is a very decent dose, but some people only need 10 mg and others need hundreds to get anywhere.\n\nSunnyizzy3\n_____________________\nThis is highly variable based on the person and also based on the form of consumption. For instance, take an edible which is metabolized by liver. \n\nIt is said, that THC is actually stronger when consumed this way than by smoking or vaping, based on how your body processes it. With an edible, 5mg for me is enough to make me feel stoned and want to go to sleep. For others, this low dosage may not be felt at all. Other people may be able to consume up to 100mg of THC per day and still function. It really depends on your system.\n\nIn terms of smoking, again this is variable. I am unable to smoke typical strains of THC which may be at 18% THC whereas my partner can smoke a whole joint and be functional.\n\nThe best way to determine what is right for you is to always go low and slow. Start at a bare minimum dosage and wait to feel the effect. Then go from there.\n\nI hope this helps!\n\nPamela Hadfield\n_____________________\nIf you roll your own, you can calculate the quantity of THC based on the amount of cannabis you are putting in the joint and the concentration of THC known to be in the strain you are using. \n\nIf you are referring to the average dispensary pre-roll, you are talking about 750mg - 1g of cannabis per joint. The average THC concentration in today's strains is around 12%, which is about 3-4 times as potent as strains a couple decades ago. Using these numbers, this means that your typical pre-roll will have approximately 100mg of THC. Some strains have a THC concentration upwards of 25%. \n\nThe bottom line is, a lot! Caution is advised, and many patients will use one joint over several days for this reason. \n\nIn general, I discourage smoking, because marijuana smoke contains carbon monoxide, tar, carcinogens and other chemicals which may be toxic and damaging to body tissues. Vaporizing shredded flower or CO2-extracted oil concentrates are considered safe alternatives, as we are not aware of any damaging substances in marijuana itself. Vaporizers control the temperature of your medicine such that it only turns into vapor, akin to water turning into steam; and they do not burn the cannabis. Therefore, no smoke with its potentially harmful products of combustion is created.\n\nDr. Edmunds\n_____________________\nFlower typically has 12% to 28% THC. In other words, that's 120 mg to 280 mg per gram of flower. And edibles get metabolized by the endocannabinoid system way differently so don't start out with apples to apples dosage from flower to edibles. Start small like 15 mg...wait up to 2 hours, then take more and figure out your own titration. Every person I know has a very uncomfortable story regarding over-medicating on edibles. Later, everyone will tell their story and laugh, but it's not funny at the time.  If you over medicate; eat, drink lots of water, some people say drink orange juice and just hold on to your hat, it will pass, and you'll get through it. Some people also say having CBD on hand will counteract the over-medication of THC, so it's good to have that handy. I haven't personally tried CBD when I've over-medicated, which has been about 3 times total in my experience of dabbing/vaping concentrates or eating edibles.\n\nCheri Devine\n_____________________\nLet me talk about the second part of your question. At first impulse it makes sense to try and match your THC milligram dosage with your edible dosage to experience a similar result. However, when THC is metabolized in the liver it is converted into 11-Hydroxy-THC. This particular cannabinoid passes through the blood-brain barrier much more efficiently than THC. As a result the high can be much more intense. If we take Dr. Edwards calculation and apply it to your edible dose then you would start your dosing at 120mg. That is dangerously strong for someone who is not experienced with edibles. \n\nEdibles are a whole other experience than smoking so you should start with a very low dose and work your way up from there. Pick out something easily measurable, like a chocolate bar. Plan a day to take it and see how it affects you over the course of a few hours. The next day adjust your dosage accordingly, but probably only in 2.5-5mgs. These may seem like low dosages, but some people can be very sensitive to the effects of 11-Hydroxy-THC. When I eat edibles with one of my friend's we always have to give her less than 7mg, despite that she smokes several times a week. Otherwise the effects are far too strong.\n\nRyan\n_____________________\nEdibles vs smoked can not really be compared. When you eat it you get the full dose of the edible. The dose in a joint depends on weight of joint ÷ percentage of thc (1gram/.20) 200mg thc \n\nMb Davison\n_____________________\n7\n\nMike Twist\n_____________________\nHi there!\n\nIf you are trying to calculate the amount of milligrams of THC in a typical joint, there are a few variables that you will need to take into consideration.\n\nThe first thing to keep in mind is that THC levels of cannabis flower vary by each strain used. Certain marijuana strains may not be as potent as others, and if you are consuming a CBD strain, there will be significantly less THC present.\n\nAnother factor to remember is how frequently you are smoking the joint. It can be difficult to estimate the EXACT amount of milligrams of THC present in a joint, as you can lose up to 40-50% of THC in between inhales. With that said, as your joint gets smaller, THC will become condensed towards the end, so your second half of the joint would test higher milligrams of THC present than the first half.\n\nUnfortunately, there is not a definitive answer to calculate your exact tolerance level of edibles when compared to joints. Please keep in mind that your tolerance of smoking cannabis may not be parallel to your tolerance for consuming cannabis-infused edibles. However, when it comes to marijuana edibles, I would suggest starting with a very low dose, perhaps 2 or 5 milligrams and slowly increase after 1-2 hours. You will need to wait for some time to experience psychoactive effects as THC is processed through the liver before it enters your bloodstream.\n\nI hope this information helps! :-)\n\nVeronica B","image":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.3888888888888888,"src":"/static/67505738d878135621c0f62deea9114f/38022/0c43cb92e2cb19a5281ba36642d57f33.jpg","srcSet":"/static/67505738d878135621c0f62deea9114f/f836f/0c43cb92e2cb19a5281ba36642d57f33.jpg 200w,\n/static/67505738d878135621c0f62deea9114f/2244e/0c43cb92e2cb19a5281ba36642d57f33.jpg 400w,\n/static/67505738d878135621c0f62deea9114f/38022/0c43cb92e2cb19a5281ba36642d57f33.jpg 547w","srcWebp":"/static/67505738d878135621c0f62deea9114f/3acbe/0c43cb92e2cb19a5281ba36642d57f33.webp","srcSetWebp":"/static/67505738d878135621c0f62deea9114f/61e93/0c43cb92e2cb19a5281ba36642d57f33.webp 200w,\n/static/67505738d878135621c0f62deea9114f/1f5c5/0c43cb92e2cb19a5281ba36642d57f33.webp 400w,\n/static/67505738d878135621c0f62deea9114f/3acbe/0c43cb92e2cb19a5281ba36642d57f33.webp 547w","sizes":"(max-width: 547px) 100vw, 547px"}}}}},{"node":{"id":"Question_10806-markdown","title":"Have been taking CBD for a year in tincture form but can find no information on dosage.","slug":"have-been-taking-cbd-for-a-year-in-tincture-form-but-can-find-no-information-on-dosage","content":"\"I have myelofibrosis and have been taking CBD for a year in tincture form but can find no information on dosage. Can you give me an idea?\"\n_____________________\nActually, any information given could be wrong because there is not enough information in your question to be able to answer with any certainty of accuracy. How much THC is in your tincture? \nThere should be a dose or strength listed for your CBD tincture. \nPlease, give more complete information. \nIf your cannabis is only CBD meaning it is hemp, we do not have current studies as to how much will work or even that it does work the same as CBD : THC cannabis.\nTypically, a dose of CBD will last 4-6 hours.\n\ndrolson","image":null}},{"node":{"id":"Question_10783-markdown","title":"What dosage and daily  frequency do you  recommend for insomnia  using cannabis? ","slug":"what-dosage-and-daily-frequency-do-you-recommend-for-insomnia-using-cannabis","content":"\n_____________________\nUsually, insomnia is due to anxiety, stress or pain, when the brain is overactive and you need it to shut up so you can go to sleep. You want to treat the inflammation and pain with CBD cannabis especially the salve or balm applied before bedtime while you are also working at the laminating inflammatory foods from your diet. The anxiety and stress maybe trying to communicate something to you and then I wonder if you should actually ignore it or pay attention. Are you doing the work you came here to do in this lifetime or have you settled for less? If you know you are in the wrong job, wrong relationship or just not taking care of yourself maybe you want to get back on track instead of ignoring the symptoms. Have you been doing too much THC? THC is very overstimulating. I find a lot of patients you have insomnia are using Sativa cannabis and then following with Indica but that's a big mistake. The THC in the Indica will boost the THC up from the Sativa over stimulating your brain. After using Sativa, try using a healthy dose of CBD, because a high CBD/ low THC tincture will combine with the high THC in the Sativa to make an Indica and you will go to sleep.\nIt is always good to take a cannabis holiday when you do not do any cannabis. \nThis method of using your medication will likely help you sleep better because you are addressing the reasons you experience insomnia.\n\ndrolson","image":null}},{"node":{"id":"Question_10745-markdown","title":"For glaucoma, if the dosage is 4x per day, what would be the dosing schedule since the effect only lasts 3-4 hrs?","slug":"for-glaucoma-if-the-dosage-is-4x-per-day-what-would-be-the-dosing-schedule-since-the-effect-only-lasts-3-4-hrs","content":"\n_____________________\nevery 3 to 4 hours would be best so the helpful effects of the cannabis remain strongest for you\n\nweedeliverfree","image":null}},{"node":{"id":"Question_10690-markdown","title":"What is the best ratio and dosage of CBD and THC for my cancer?","slug":"what-is-the-best-ratio-and-dosage-of-cbd-and-thc-for-my-cancer","content":"\"I don't want to feel high, but I do want to feel better that I currently do.\"\n_____________________\nCan you tell me why the 12:1 CBD/THC ratio was not recommended for you? I have done some research that suggests that too high of a THC ratio can proliferate Estrogen Positive cancer. I've read a couple of websites that suggest a 3:1 CBD/THC ratio is better, however, there is not a lot of information about it. Has your girlfiend been feeling better with the 1:1 ratio at all?\n\nladyinleopard\n_____________________\nContrary to what these professionals are saying I have seen cannabis bring several people back from hell using Rick Simpson oil in conjunction with Amber oil to cure cancer including My own dad   & it's been 11 years. She must do more than use the oil. She must also consume a high alkaline diet(check out Dr Sebi) as well as making your own butter and tinctures with them(comes out way cheaper) They have this great new machine called magical butter machine. Get it use it often & God Bless FYI DR SEBI CURED CANCER WAY BACK IN THE 90's himself so if I was you I'd do some due diligence on the research tip. God Bless\n\nsirkofyork\n_____________________\nStage 2 prostate cancer, or cancer that has not grown outside the prostate capsule and have a higher PSA level then 10. As with stage I cancers, active surveillance is often a good option for men whose cancer is not causing any symptoms and who are elderly and/or have other serious health problems. Radical prostatectomy and radiation therapy (external beam or brachytherapy) may also be appropriate options.\n\nUsing THC or CBD oil and suppositories are unproven ways to treat prostate cancer. In other words there have never been human clinical trials using cannabis to treat prostate cancer. That being said, the other question would be is there any harm in using them? As far as I can tell the answer is no. The primary thing to remember is to be in contact and follow up with your urologist so that they can keep an eye on your condition and not to rely on any cannabis product to be the only modality to treat any type of cancer.\n\nPerry Solomon, MD\n_____________________\nI am sorry to hear that has occurred. There have been no studies on humans as to the effectiveness of cannabis to treat any type of cancer, including prostate cancer. There is anecdotal reports of patients who have used Rick Simpsons oil to help treat prostate cancer instead of having prostate surgery when the cancer is isolated to the prostate and not spread. I am sure that your urologist and oncologist have recommended treatment that they have found to be helpful when the cancer has spread to the bones. That being said, there is no downside to using cannabis if you are looking to some pain relief if the cancer is causing you bone pain. Using a 1:1 CBD/THC ratio may give you pain relief.\n\nPerry Solomon, MD\n_____________________\nIdeally, your wife should be in a research study because there is a lot happening right now regarding ovarian cancer. \nBoth THC and CBD appear to be toxic to cancer cells but obviously a lot more research needs to be done. The biggest problem with ovarian cancer is the development of resistance to the chemotherapy so lots of research is being done on immunotherapy but she can be on the cannabis oil or a tincture now.\nUnfortunately, no one can tell you exactly how the Cannabis should be taken for optimal outcome. To be functional it makes sense to do CBD during the day when things have to be done and THC can be added when she does not have to drive or do business. CBD is great for stopping pain and inflammatory symptoms and it will calm anxiety and THC can give a nice uplift with a happy mood. CBD: THC in a 8:1 nonalcoholic tincture oral spray can work well in place of nonsteroidal anti-inflammatory drugs and she will not be hi; 4:1 works well for inflammation and pain but it will be psychoactive; 2:1 is psychoactive but may really help her attitude relax yet allow her to get things done around the house like fixing a nice meal and being with the family.\nI think anyone can use our full website but I am asking the office for clarity since I'm not 100% certain, I'm just one of the doctors here and I may not be aware if there's a portion of the website that is unavailable for out-of-state clients.\n\ndrolson\n_____________________\nI'm very sorry to hear of your health challenges. Your situation must be approached from many directions for true success. A high percentage of breast cancer cases our link to a deficiency of vitamin D and if the vitamin D level is not corrected you're more likely to experience metastasis and if it's still not corrected you have a higher risk of dying from vitamin D deficiency but it will be listed as breast cancer because most doctors do not know how to treat vitamin D deficiency. For optimal health your blood level of vitamin D must be above 50 ng/mL and that usually requires the supplements of about 10,000 international units of vitamin D3 per day.\nDo high CBD low THC in a nonalcoholic tincture (my preference is medium chain triglyceride oil from coconut) 2 to 3 times per day for optimal support of your immune system, pain relief, anxiety and stress relief as well as protection for your cardiovascular and neurological systems. You will not feel psychoactive effects with high CBD cannabis but if you would like a psychoactive effect you can always add more THC.\nPlease read a book, \"Sex, Lies and Menopause\" by Wiley and Taguchi and consider a second opinion with Dr. Taguchi, who happens to have the longest live breast cancer patients because she re-balances their hormones with true bio identical's to their 20 year old level of hormones proving that peaking the true bio identical estradiol and bio identical progesterone actually stimulate P 53 the guardian of your genome to cause involution of your cancer cells. \nThis does not mean that you forgo western treatment because that actually will be necessary but the cannabis will help you greatly and as soon as you are finished with your treatments you should consider starting on the Wiley protocol to keep the cancer from ever returning.\nGood luck, you have a lot of reading ahead of you and lots of decisions to make but the high CBD cannabis will keep your brain sharp and focused helping you make your decisions.\nDon't hesitate to stop doctors if they try to put a lot of negative suggestions in your brain, You have the right to request that they stay on the positive side to help support you, and not break you down.\n\n\ndrolson\n_____________________\nBoth  CBD and THC have demonstrated anti-proliferative activity in animal studies, however, there are no clinical trials to establish the optimal ratios of THC:CBD in treating cancer in humans. Most of the available literature is based on anecdotal evidence and recommends using a ratio with the maximum amount of THC that is tolerated.  I would suggest starting with a THC:CBD ratio of 1:10 - 2.5mg THC: 25mg CBD and increasing that dose as tolerated. Realm of Caring recommends a CBD dose of 50mg twice daily. I have a patient with Hodgkin's lymphoma that has responded to this dose, which is very low when compared to the Rick Simpson protocol of 60 grams (60,000 mg).   With high THC doses, the most significant side effects are going be mental impairment and possibly low blood pressure and heart rate that may cause dizziness, light headedness, or fainting. Also, I'd like to mention that  European studies have shown that in animal models, CBDa, the acidic precursor to CBD has even higher anti-tumor and anti-inflammatory activity than CBD. \n\ndrfrye\n_____________________\nYou're right that this is a very complicated and controversial issue and unfortunately, there is no clear cut answer.  \n\nMost evidence supports CBD as being a key anti-tumor agent in marijuana and has been acknowledged as such by the National Cancer Institute.  The American Association of Cancer Research published a paper demonstrating that CBD inflicts programmed-cell death in breast cancer cells, regardless of Estrogen receptor positivity, while preserving normal breast cells.  \n\nTHC also has anti-tumor properties and inhibits cell cycle progression in breast cancer cells. It has been said that THC may increase estrogen levels and may promote breast cancer growth in ER+ tumors, but there is not strong evidence to support this statement. \n\nUnfortunately, much more research will need to be done before we can provide any clear guidance on what the \"correct\" ratio of CBD/THC might be (if there is one) for the treatment of specific types of cancer.  I would approach it from a tolerance standpoint and also one that provides symptomatic relief of pain and/or treatment side effects.  In general, this would mean a higher ratio of CBD/THC while at the same time minimizing psychoactive effects of THC.  \n\nIt is true that the rectal suppositories provide greater bioavailability (upwards of 70%)  than inhaled or ingested cannabis (approximately 20%).  \n\nRick Simpson's oil is a full-plant cannabis extract containing high amounts of THC, CBD, and other cannabinoids.  It differs from CBD-oil which is often extracted from hemp and contains (mostly) CBD. The theory behind Rick Simpson's oil is to provide the patient with maximum possible amounts of all cannabinoids, in a more nature balance that is found in the plant.  Another theory is that cannabinoids work synergistically, which would support the use of such a product.  \n\ndredmunds\n_____________________\nI recently tried to answer a similar question for the treatment of stage 4 breast cancer... Unfortunately, there is not a defined ratio of CBD/THC nor known dosing that is optimal for different types of cancer. Both CBD and THC have anti-tumor properties and may work synergistically. \n\nRick Simpson's oil has a high concentration of THC, CBD, and other cannabinoids and has been touted as being effective not only because of these high concentrations but because it is a \"whole-plant\" extract. \n\nBecause THC is the main psychoactive ingredient in marijuana, some patients don't tolerate high concentrations of THC well.  My general suggestion is to consider what is tolerable for any given patient on an individual basis and to focus on symptomatic relief of pain and/or side effects of treatment, including chemotherapy. Many patients have been able to tolerate chemotherapy much better while supplementing with cannabis.  \n\ndredmunds\n_____________________\nWe have been receiving a lot of questions similar to yours for a variety of different types of cancer, and appropriately so! You may want to refer to my answer to a couple questions recently on breast cancer and throat cancer, and Dr. Frye's answer to one regarding brain cancer. \n\nThe bottom line is, there is no \"best\" ratio known.  Clinical trials will need to be performed in humans to help us understand what ratios and/or dosages are most effective in different types of cancer.  We do know that in-vitro studies have demonstrated both CBD and THC to have anti-tumor properties, and there is anecdotal evidence that certain patients have had cancer go into remission following cannabis therapy. \n\nIn general, I recommend dosing according to what an individual patient can tolerate, which usually is a high CBD/THC ratio, because THC in high doses can have undesirable effects for many patients.  Also, many patients find that chemotherapy side effects are more tolerable when supplementing with cannabis.  If you are going to be working and/or driving while undergoing cannabis therapy, I would strongly encourage you to avoid THC during these times for obvious safety reasons.  \n\ndredmunds\n_____________________\nFECO or Full extract Cannabis Oil or Hash Oil, Hemp oil or Rick Simpson Oil has gained much attention as a potential treatment for many forms of cancer. Patients have shared their success stories in treating their cancer with this healing oil. Not only does FECO help patients deal with the side effects of conventional cancer treatment (nausea, poor appetite, vomiting, pain, depression, anxiety, insomnia, to name a few), it also shows promise in helping to eliminate cancerous cells, prevent metastasis of exsiting cancer, and in preventing angiogenesis (formation of new blood vessels that feed cancerous growth). With FECO dosing can be difficult, but from my experience it seems that more is better, and patients should try to ingest as much oil as possible, while remaining functional and comfortable. No potential for overdose exsists, but extreme psychoactive effects are often not desired. As much variability exsists in the quantities of THC and CBD, and in extraction techniques, it is best to start low and slow and gradually increase the dose as tolerance is built up. \nDosing should be three times a day, with the goal of about a gram a day, with the goal of ingesting at least 60 grams of oil in total. Each patient is different, and variability in the potency of the oil can be significant. As such, dosing should be optimized to each patient's situation and goals.\n\nandrewvanmd\n_____________________\nIn response to @scotter1 comments. While it is always thrilling to see that people have responded in some way to different treatments for cancer, breast or otherwise, it is very important to remember that cannabis has never been shown to \"cure\" cancer in humans. A \"cure\" by most definitions is cancer-free for 5 years. There have been many many anecdotal reports from people reporting this as well as labs, etc. The main point to remember that it is important consider using cannabis in any form, in conjunction with proven medical treatments when there are not reactions between the two.\n\nThe main difficulty in proving that cannabis works is the Schedule 1 label that cannabis has and the tremendous difficulty that surrounds having studies approved. And even when they are the results can be several years down the road. I applaud people who have the open mind to try cannabis to help treat their diseases but also do not want them to ignore, refuse or stop taking proven medical ones.\n\nPerry Solomon, MD\n_____________________\nI think CBD is better in higher ratio for cancer if all you are looking for is to kill cancer cells.  I think THC helps manage some of the side effects though.  check out projectcbd.org.    I really believe in the power of this plant's medicine. Also, reduce sugar and alkalize your body.  Best of luck with your health.\n\ngenabedon\n_____________________\nAt this point it is important to remember that part of what you are doing with cannabis is improving quality of life. The science is exciting but lacking in detail it can only be used to point you in the right direction. Your decisions will have to be based on something and your girlfriend's 'experience' of the medicine can be part of your guide. What makes her feel better?\n\nI recommend Uwe Blesching's book: Cannabis Health Index http://cannabishealthindex.com/\n\neden\n_____________________\nCBD or cannabidiol is a non-psychoactive compound found in certain strains of cannabis that has potent anti-inflammatory and anti-anxiety effects. Inflammation is the underlying cause of many diseases and conditions. Try tinctures with various ratios to see what works best for you. CBD has very different effects than THC, mainly because of the way it interacts with our endocannabinoid system. CBD works to increase the levels of our bodie's own cannabinoids (endo-cannabinoids), by preventing their breakdown.\n\nandrewvanmd\n_____________________\nI am not a doctor so I can not comment on CBD vs THC for cancer cells. I would recommend that you read the following articles on Project CBD. I often refer to \nProject CBD for articles on CBD and cancer:\nhttps://www.projectcbd.org/cancer\n\nThere are many scientific studies that indicate CBD can inhibit cancer cell growth, but these are most often within lab rats or petri dishes. There is a lot of anecdotal story telling around CBD/THC stopping cancer in its tracks or putting it into remission, but these are not based on any clinical trials or concrete evidence (I do not stand agree or disagree with people's experience). There are new studies underway and one in particular of interest is being done regarding cannabis in conjunction with traditional treatment methods on melanoma and can be viewed in this HelloMD news segment:\nhttps://www.hellomd.com/health-wellness/hellomd-live-episode-8\n\nI can speak from my own experience that for inflammation a high CBD ratio tincture works very well. I typically consume a 20:1 2x a day for inflammation and I take a low dose of THC every day 2x a day of 2.5 mg which will not have any noticeable psychoactive effect but it does decrease anxiety. \n\nTo answer your question more specifically, I would be consuming both CBD and THC as both have systematic effects that may help you. This is called the entourage effect, in that they work together to create homeostasis within the body. \n\nI hope this helps!\n\npamelahadfield\n_____________________\nSince we have been profoundly handicapped in this country by not being able to do clinical trials regarding the benefits of cannabis, I don't think anyone has a hard and fast rule around the best ratio of CBD to THC for brain cancer. We do know that CBD does stop some brain cancers and may protects the brain from further damage. The higher the concentration of CBD the more pervasive it is. Rick Simpson oil tends to be a 1:1 ratio but most of the stories of cancer cures are antidotal. I understand that clinical trials are being conducted in Israel so in the meantime consider using your cannabis to buy time in hopes that we will have a more definitive answer in the near future. Since activities are limited when using THC because you're not allowed to be high in public, I think it is wise to take high CBD during the day and you can do more THC at home. Remember to always follow high THC with high CBD if you want to go to sleep because that will make an Indica in your body.\n\ndrolson\n_____________________\nUnfortunately, there is no exact answer for this question. Many people will use Rick Simpson oil and overtime you will become adjusted to the high so you can function on a day-to-day basis. Chemical testing should have been performed on the oil if you buy it in California through a dispensary or delivery service. Both THC and CBD are toxic to cancer so I give patients the option of going on a super high CBD for daytime use along with RSO for afternoon and evening or CBD during the day and a Sativa in the afternoon returning to CBD at night. I think as long as you're taking high-dose is of cannabis it does facilitate your immune system in reversing your disease state but until we can actually do clinical trials, keep in mind we are handicapped and all we can truly offer are antidotal stories. I'm certain you want more assurance than just an antidotal story. Most research is being done in Israel at this time but a few clinical trials have been started in the United States, I just can't tell you if they involve your type of cancer.\nJeanne Achterberg taught us that imagery also works when you're fighting cancer. When you take a dose of cannabis, Image that each drop is filled with millions of little, microscopic dogs that love you and their whole purpose in life is to help you live by running through your body and eating any cancer cells or cancer garbage they find especially since this is what dogs are good at, eating garbage and loving you for the opportunity. Keep your determination strong and you should be able to overcome the cancer and even buying a couple of years me produce profound benefits for you because our knowledge is increasing exponentially. I had one patient that was able to successfully stop her ovarian cancer by doing a medically supervised fast for 40 days but I'm not advising that for you, I am encouraging you to find what is going to work for you and believing it 100% and then allow it time to work. If you do high CBD, you will not feel the medicine for almost 3 weeks, don't give up. You are in the battle that is worth fighting, I just wish we had more answers for you.\n\ndrolson\n_____________________\nI am so sorry for anyone who has pancreatic cancer since my Father and his only sister both had pancreatic cancer so I have watched it first hand but that was more than 30 years ago and we have come a ways since then especially with cannabis. We have been lacking credible research studies but one research study has been started in Australia by Chris O'Brein Lifehouse that will study the effects of cannabis on pancreatic cancers. \nSince all cancers involve inflammation, CBD or cannabidiol or THCa from juicing green cannabis buds may help to reduce inflammation there by giving relief from the pain and potential GI obstruction.  In addition, I highly recommend the topical cannabis salve that is slightly dominant in CBD. Rub the salve on your upper abdomen between the ribs and the area of the upper back that corresponds to the 'bra line on a woman' but applying the salve throughout the posterior thoracic spine to stop the pain is greatly beneficial and should be done frequently at first and as the pain is coming under control you may start to spread out the application of the salve. For me, the more I use the salve the more effective the salve is and the longer the pain blocking effect works. The salve will not go systemic on anyone who applies it for you and there will be people who want to help you out in any way they can so please, put them to work applying your salve. If there is some fear of potential contamination with the cannabis, you may supply some gloves.\nIf you are experiencing too much nausea to do the tincture orally, you could vaporize high CBD cannabis like AC/DC, 30 parts CBD to 9 parts THC, so you may be a little tipsy but you likely will be out of pain in about 10-15 minutes and the AC/DC will calm anxiety so consider a high CBD vaporizing pen for fast relief. Remember, CBDs must be vaporized at a lower temperature or the quality of the CBD will be lost so have someone help you with CBD vape pens if needed. \nGood luck, you need to buy time to stay around since there is so much work being done on finding the correct treatment for pancreatic cancer. Hold intention to live and use your mind to be positive to keep your immune system healthy and strong. You may want to do searches on the net for papers you can read on treatment of pancreatic cancer using integrated medicine as well as all the big tools of Western medical treatment because a lot of support is done with healthy nutrition, digestive enzymes and positive imagery and other treatments.\n\ndrolson\n_____________________\nMy husband has had good luck controlling the growth of his metastatic colon cancer that has spread to his liver with Cannabis oil. We used 3 different oils for maximum exposure to different terpenes.  I would have liked him to try suppositories also, but he is \"Rectal-phobic\".  The oil was taken by capsule. Three times daily.\n\njeroling\n_____________________\nI'm sorry to hear you have been diagnosed with breast cancer. There is no reason to smoke or drink. A whole-foods, plant-based diet has been shown to be beneficial for managing cancer symptoms such as pain, fatigue, and apoptosis (cancer cell death.) \n\nnixie\n_____________________\nThe best dosage or best CBD to THC ratio for cancer has many anecdotal answers.  If you are looking for a science-based answer regarding using cannabis in cancer please read Dr. Solomon's answers on this thread. We do know the \"high\" from THC is definitely modified in character and intensity by the presence of CBD, so finding the right CBD to THC ratio for you would be important. As Dr. Solomon notes, cannabis has a remarkably benign toxicity profile - although too much can be unpleasant there have never been any reports of poisoning or organ damage despite many years of widespread use of the plant. This makes it safe to experiment freely, but still offers no way to judge different recommendations, such as best CBD:THC ratio for cancer.  I am usually an \"entourage effect\" proponent, unwilling to exclude part of the plant when I don't fully understand what all the parts contribute, so I'm inclined toward more holisitic, \"whole plant\" preparations. Some varieties are bred to express mostly CBD, so you can still manipulate the CBD:THC ratio by including those. I also think of cannabis as an excellent mood moderator, better than many medications taken daily for this purpose, and in treating cancer I see an important role for this action both for patient comfort and to support the well established relationship between positive attitude and better survival in cancer.   \n\ndrelkind\n_____________________\n \nMy mother was diagnosed in May of 2013 with 4 Cancer.She was given 3  to 6 months to live,not because of spreading but because of the location  of the tumor, it is abutting the aorta. she is 53 and also has MS.I  succeeded in saving her life by getting Rick Simpson Oil from this guy  in California.You can contact him if interested in getting some Oil:\nEmail... tplug05 at gmail dot com .\nPhone.....+1(559)420-0769 .\n\n\nJones leton90\n_____________________\nMy mother was diagnosed in May of 2013 with 4 Cancer.She was given 3 to 6 months to live,not because of spreading but because of the location of the tumor, it is abutting the aorta. she is 53 and also has MS.\nI succeeded in saving her life by getting Rick Simpson Oil from this guy in California.You can contact him if interested in getting some Oil:\nEmail... tplug05 at gmail dot com .\nPhone.....+1(559)420-0769 .\n\n\nalison leton","image":null}},{"node":{"id":"Question_10635-markdown","title":"Frequency of medicating?","slug":"frequency-of-medicating","content":"\"After years of therapy and taking various prescription medications, I've recently turned to MMJ to supplement the treatment of my anxiety and depression.  Since I am new to this, I was wondering if you have any recommendations as to the frequency or dosage when medicating myself.  For example, would it be more beneficial to medicate when I feel a panic attack beginning or when I have a particularly down day, or to medicate regularly (i.e. daily, like taking my daily antidepressant)? Thank you! \"\n_____________________\nThis is a question that we see frequently. It really depends an the type of method that you are suing to consume cannabis.\nSmoking or vaping may be more appropriate when feeling a panic attack coming on since the effect takes place almost immediately. The effect last 2-4 hours which may be enough time for a panic attack to subside. \nA tincture will take about 20-30 to take effect and can last about the same time\nA capsule can take about the same time to take effect or maybe slightly longer and can last shout the same amount of time. \nEdibles can take 1-2 hours to start and can last 3-6 hours depending on your metabolism.\n\nWith any of these methods, and for any medical condition, we suggest starting with a low dose and going slow to increase the dose. Every one reacts differently to cannabis and what works for one person might not fwork for another. When you visit your dispensary, describe to the bud tender there what your medical condition is and what they carry to help treat it. They will also help you decide on the best way to use he cannabis in terms of time to take effect and how long it will last.\n\nPerry Solomon, MD","image":null}},{"node":{"id":"Question_10572-markdown","title":"Can my my daughter us CBD oil as a replacement for Remicade?","slug":"can-my-my-daughter-us-cbd-oil-as-a-replacement-for-remicade","content":"\"My Daughter has Ulcerative Colitis. She is on Remicade but still has bleeding. I have  heard about CBD oil. We live in New Jersey . How can I get information about purchase and dosage. \"\n_____________________\nInflammatory bowel diseases such as Crohn’s and Ulcerative Colitis, are immune deficiency diseases that involves chronic inflammation of the gastrointestinal tract. They can cause persistent cramping, diarrhea, obstruction, and rectal bleeding.\n\nPatients suffering from Crohn's disease, or from any type of irritable bowel disease, have a higher level of cannabinoid receptors in their gastrointestinal tract. The endocannabinoids found in cannabis can help to reduce the inflammation caused by these conditions. In 2013, the journal Clinical Gastroenterology and Hepatology found that 10 of 11 patients in the cannabis group of a study had a significant reduction in their symptoms and 5 had complete remission with the use of cannabis.\n\nOur body has its own cannabinoid system referred to as the endocannabinoid system and we have cannabinoid receptors, CB1 and CB2, in the digestive system. The cannabinoid system has been shown to be involved in regulating the immune system through its immunomodulatory properties. Cannabinoids suppress inflammatory response and reduce disease symptoms. This happens through multiple, complicated biochemical pathways.\n\nWhen CB1 receptors are activated, they can decrease intestinal movement and the secretion of intestinal fluids. CB2 receptor stimulation can lead to an increase in T-cell, white blood cells, and other body cells that mediate inflammation. There is also evidence that THC may be helpful in reducing the leakage of fluids through the lining of the gastrointestinal tract.\n\nRemicade, or infliximab, is a monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, ankylosing spondylitis and plaque psoriasis of the skin. Remicade is often used when other medicines have not been effective. It blocks the action of a protein in your body called tumor necrosis factor-alpha (TNF-alpha) reducing inflammation and altering immune response. Common side effects of Remicade include headache, stomach pain, nausea, stuffy nose, sinus pain, skin rash, or flushing.\n\nDue to stomach sensitivities in patients with Crohn’s, vaporization or smoking has seemed to be the best delivery method for medical cannabis. Edible forms, however, allow for the cannabis to directly sooth the gastrointestinal tract. \n\nInflammatory Bowel Disease is a qualifying condition in New Jersey for Medical Marijuana and your state has licensed dispensaries.\n\nWhile I would recommend using CBD oil as an adjunct to current therapies, I have had good results for patients using CBD Oils in a 2:1 ratio several times per day with the addition of some THC pills in extracted form in capsules for flares and to stimulate appetite and sleep. \n\n\ndrbluto","image":null}}]}},"pageContext":{"limit":12,"skip":168,"numPages":15,"currentPage":15,"id":5206,"name":"Dosage","slug":"dosage","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}