{"componentChunkName":"component---common-build-questions-template-js","path":"/questions-and-answers/can-cbd-help-manage-irritable-bowel-syndrome-ibs","result":{"data":{"question":{"title":"Can CBD help manage Irritable Bowel Syndrome (IBS)?","slug":"can-cbd-help-manage-irritable-bowel-syndrome-ibs","createdAt":"October 8, 2020","image":null,"tags":[{"id":5084,"name":"CBD","slug":"cbd"},{"id":5369,"name":"IBS","slug":"ibs"},{"id":5394,"name":"Irritable Bowel Syndrome","slug":"irritable-bowel-syndrome"}],"childMarkdownRemark":{"excerpt":"\"Thank you!\" Hi there!\nYes it can. It all boils to the endocannabinoid system  (ECS). The ECS is largely devoted to…","html":"<p>\"Thank you!\"</p>\n<hr>\n<p>Hi there!\nYes it can. It all boils to the endocannabinoid system  (ECS). The ECS is largely devoted to maintaining homeostasis (the  tendency of organisms to auto-regulate and maintain their internal  environment at equilibrium). Deficiency or malfunction of the ECS has  become a focus for researchers seeking treatment options for several  maladies—especially those that have few, if any, effective  pharmocotherapeutic interventions, such as celiac disease, MS,  fibromyalgia, IBD and IBS. In fact, the scientific community has  recently termed the ECS malfunction: Clinical Endocannabanoid  Decifiency, or CEDC.</p>\n<p>CBD works by balancing and supporting the  ECS through its subtle effects on cannaboinoid receptor-1 (CB1) and  cannaboinoid receptor-2 (CB2) receptors, as well as other receptors that  modulate serotonin, GABA, dopamine, and many more.</p>\n<p>In IBS, IBD  and GERD, like most every physical-chronic condition, inflammation is  central to both the etiology and symptomology of the respective disease.  CBD works to reduce inflammation by restoring balance to the ECS.</p>\n<p>drkim</p>\n<hr>\n<p>The main culprit for acute and chronic inflammation in the gut is  hyperactive enteric glial cells, which proliferate and release  neurotrophins, growth factors, and pro-inflammatory cytokines that may  overamplify the immune response. Recent pre-clinical research suggests  that CBD may lower GI inflammation by controlling reactive gliosis in  the enteric (GI) nervous system. Or, in other words, CBD restores  homeostasis in the gut by reducing hyperactivity in enteric glial cells.</p>\n<p>Furthermore,  several studies show that among patients who seek medical attention for  IBS or IBD, around 70% of IBS patients, and 30% of IBD patients, have  psychiatric comorbidity—depression and generalized anxiety disorder  being most common. CBD increases serotonin signaling at the 5-HT1A  receptor—the same neurotransmitter and receptor that SSRIs like Prozac  influence—which is mostly why CBD has antidepressant and anxiolytic  properties. In fact, SSRIs and tricyclic antidepressants (which also  increase serotonin signalling), have been shown to alleviate anxiety and  depression symptoms, as well as alleviate some of the abdominal pain  and bowel symptoms involved in IBS, IBD and gastroesophageal reflux  disease (GERD), which is why SSRIs and TCAs are commonly prescribed for  IBS and IBD.</p>\n<p>I hope this helps!</p>\n<p>drkim</p>","timeToRead":1}},"defaultImage":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.5,"src":"/static/1e164eb4ee29aff63b63675577d389d3/a07a5/question-default-image.jpg","srcSet":"/static/1e164eb4ee29aff63b63675577d389d3/decd9/question-default-image.jpg 150w,\n/static/1e164eb4ee29aff63b63675577d389d3/15aed/question-default-image.jpg 300w,\n/static/1e164eb4ee29aff63b63675577d389d3/a07a5/question-default-image.jpg 600w,\n/static/1e164eb4ee29aff63b63675577d389d3/701ee/question-default-image.jpg 800w","srcWebp":"/static/1e164eb4ee29aff63b63675577d389d3/483a3/question-default-image.webp","srcSetWebp":"/static/1e164eb4ee29aff63b63675577d389d3/e8bcc/question-default-image.webp 150w,\n/static/1e164eb4ee29aff63b63675577d389d3/4fec1/question-default-image.webp 300w,\n/static/1e164eb4ee29aff63b63675577d389d3/483a3/question-default-image.webp 600w,\n/static/1e164eb4ee29aff63b63675577d389d3/2ad7f/question-default-image.webp 800w","sizes":"(max-width: 600px) 100vw, 600px"}}}},"pageContext":{"id":12308,"slug":"can-cbd-help-manage-irritable-bowel-syndrome-ibs","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}