{"componentChunkName":"component---common-build-questions-template-js","path":"/questions-and-answers/cannabis-interaction-w-amittriptyline-propranolol","result":{"data":{"question":{"title":"Cannabis Interaction w/ Amittriptyline & Propranolol","slug":"cannabis-interaction-w-amittriptyline-propranolol","createdAt":"October 8, 2020","image":null,"tags":[{"id":4940,"name":"Amitriptyline","slug":"amitriptyline"},{"id":5052,"name":"Cannabis","slug":"cannabis"}],"childMarkdownRemark":{"excerpt":"\"Does Cannabis have interactions with medications Amitriptyline and Propranolol? If so what are that are the side…","html":"<p>\"Does Cannabis have interactions with medications Amitriptyline and Propranolol? If so what are that are the side affects? Can it be taken at the same time? \"</p>\n<hr>\n<p>All three items (cannabinoids like CBD &#x26; THC) as well as amitryptylline &#x26; propranalol are all metabolized by an enzyme in the liver known as CYP2D6.  The drug monographs for both propranolol &#x26; amitriptyline already warn that both of these medications used together can cause high plasma levels of the amitryptylline because of down-regulation of said enzyme.  Cannabis, in the literature, has also been shown to decrease function of this enzyme &#x26; theoretically, this could also increase the plasma amitriptyline levels (although this was just in an experimental lab setting).  I would bring these issues up to your primary MD and let them make any needed drug adjustments.  I hope this helps!</p>\n<p>drpark</p>\n<hr>\n<p>Hello,\nYou can safely take cannabis with both amitriptyline and propanolol. Cannabis can increase the serum levels of certain medications -- including amitriptyline and propanolol -- that are metabolized by a network of liver enzymes called the Cytochome P450 system. However, that effect would only occur if taking exorbitant amounts of cannabis -- likely well over 300mg/day. </p>\n<p>drkim</p>","timeToRead":1}},"defaultImage":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.5,"src":"/static/1e164eb4ee29aff63b63675577d389d3/a07a5/question-default-image.jpg","srcSet":"/static/1e164eb4ee29aff63b63675577d389d3/decd9/question-default-image.jpg 150w,\n/static/1e164eb4ee29aff63b63675577d389d3/15aed/question-default-image.jpg 300w,\n/static/1e164eb4ee29aff63b63675577d389d3/a07a5/question-default-image.jpg 600w,\n/static/1e164eb4ee29aff63b63675577d389d3/701ee/question-default-image.jpg 800w","srcWebp":"/static/1e164eb4ee29aff63b63675577d389d3/483a3/question-default-image.webp","srcSetWebp":"/static/1e164eb4ee29aff63b63675577d389d3/e8bcc/question-default-image.webp 150w,\n/static/1e164eb4ee29aff63b63675577d389d3/4fec1/question-default-image.webp 300w,\n/static/1e164eb4ee29aff63b63675577d389d3/483a3/question-default-image.webp 600w,\n/static/1e164eb4ee29aff63b63675577d389d3/2ad7f/question-default-image.webp 800w","sizes":"(max-width: 600px) 100vw, 600px"}}}},"pageContext":{"id":12040,"slug":"cannabis-interaction-w-amittriptyline-propranolol","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}