{"componentChunkName":"component---common-build-questions-template-js","path":"/questions-and-answers/hi-is-it-okay-to-medicate-with-thc-while-on-cialis","result":{"data":{"question":{"title":"Hi, is it okay to medicate with THC while on Cialis? ","slug":"hi-is-it-okay-to-medicate-with-thc-while-on-cialis","createdAt":"October 8, 2020","image":null,"tags":[],"childMarkdownRemark":{"excerpt":"\"...\" Hi there!\nIt is true that  THC (and CBD) can impede the metabolism of many drugs, including Cialis,  that may…","html":"<p>\"...\"</p>\n<hr>\n<p>Hi there!\nIt is true that  THC (and CBD) can impede the metabolism of many drugs, including Cialis,  that may possibly lead to an overly-high serum level of Cialis, which  can increase the risk of priapism (unresolving erection). However, that  would take a very high amount of THC—much higher than the amount you should be  taking for most reasons. However, it wouldn't be a bad idea to lower  the dose of Cialis to see if the effect were sufficient. </p>\n<p>The  cytochrome p450 system accounts for 70 to 80 percent of the enzymes  involved in drug clearance, making it the most important system for  drug  metabolism. Both THC and CBD are competitive inhibitors  of three  different enzymes in the cytochrome p450 system; the most significant enzyme of the P450 system, CYP3A4, is involved in the metabolism of THC (and CBD) and Cialis. This means that CBD and THC  are  competing for the same receptors as is Cialis. So, when Cialis is  taken concurrently with THC and/or CBD, Cialis is hindered from being metabolized, so serum concentration could possibly  rise (and vice-versa)\n<a href=\"https://ghr.nlm.nih.gov/primer/genefamily/cytochromep450\">https://ghr.nlm.nih.gov/primer/genefamily/cytochromep450</a></p>\n<p>I hope this helps!</p>\n<p>drkim</p>","timeToRead":1}},"defaultImage":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.5,"src":"/static/1e164eb4ee29aff63b63675577d389d3/a07a5/question-default-image.jpg","srcSet":"/static/1e164eb4ee29aff63b63675577d389d3/decd9/question-default-image.jpg 150w,\n/static/1e164eb4ee29aff63b63675577d389d3/15aed/question-default-image.jpg 300w,\n/static/1e164eb4ee29aff63b63675577d389d3/a07a5/question-default-image.jpg 600w,\n/static/1e164eb4ee29aff63b63675577d389d3/701ee/question-default-image.jpg 800w","srcWebp":"/static/1e164eb4ee29aff63b63675577d389d3/483a3/question-default-image.webp","srcSetWebp":"/static/1e164eb4ee29aff63b63675577d389d3/e8bcc/question-default-image.webp 150w,\n/static/1e164eb4ee29aff63b63675577d389d3/4fec1/question-default-image.webp 300w,\n/static/1e164eb4ee29aff63b63675577d389d3/483a3/question-default-image.webp 600w,\n/static/1e164eb4ee29aff63b63675577d389d3/2ad7f/question-default-image.webp 800w","sizes":"(max-width: 600px) 100vw, 600px"}}}},"pageContext":{"id":12399,"slug":"hi-is-it-okay-to-medicate-with-thc-while-on-cialis","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}