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\nPsoriasis is an autoimmune skin condition which leads to an overproduction of skin cells called keratinocytes. The immune system mistakes components of the body's own skin as pathogens, such as a virus or harmful bacteria, that need to be removed from the body. This autoimmune reaction leads to inflammation and an overproduction of skin cells, resulting in scaling, itch and pain. Between 18% and 42%of people with psoriasis develop psoriatic arthritis (PA).
\nThe endocannabinoid system (ECS) is the body's own naturally occurring network of receptors and cannabinoids that is involved in several bodily functions - immunoregulation being one of the most important and extensively studied. Several studies have shown that the CBD downregulates an overactive and self-attacking immune reaction.\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044336/
\nThe ECS is largely devoted to maintaining homeostasis (the tendency of organisms to auto-regulate and maintain their internal environment at equilibrium). Deficiency or malfunction of the ECS has become a focus for researchers seeking treatment options for several maladies, including psoriasis and PA. In fact, the scientific community has recently termed the ECS malfunction: Clinical Endocannabanoid Decifiency, or CECD. Restoring balance to the ECS with phytocannabinoids, such as CBD and THC, is the crux of medicinal cannabis treatment.
\ndrkim
\nIn fact, the phytocannabinoids THC, CBD, CBN and CBG have all been found to inhibit keratinocyte proliferation in hyper-proliferating keratinocyte cell lines, such as those found in psoriasis and PA. Among the four phytocannabinoids, CBD showed the most anti-proliferative potency, and required the lowest plasma concentration to inhibit keratinocye overproliferation.\nhttps://www.google.com/search?client=firefox-b-1-ab&q=Wilkinson%2C+J.D.%2C+and+Williamson%2C+E.M.+%282007%2C+February%29.+Cannabinoids+inhibit+human+keratinocyte+proliferation+through+a+non-CB1%2FCB2+mechanism+and+have+a+potential+therapeutic+value+in+the+treatment+of+psoriasis.+Journal+of+Dermatological+Science%2C+45%282%29%2C+87-92.
\nFurther, studies have showed that both endocannabinoids and phytocannabinoids can directly treat the symptoms of psoriasis and psoriatic arthritis, such as pain and itch.\nhttp://www.jaad.org/article/S0190-9622(17)30308-0/fulltext\nhttps://jamanetwork.com/journals/jama/fullarticle/233825
\nAnd finally, CBD can treat the the lost sleep, anxiety and depression most psoriasis patients experience. Beyond helping the patient better cope with the emotional toll psoriasis can cause, improving sleep and lowering depression and anxiety can also reduce the frequency of psoriasis flare-ups.
\ndrkim
\nThat product is an excellent choice: Rather than simply isolating CBD, Elixinol follows a \"whole-plant philosophy\" which increases the oil's medicinal properties by preserving accessory cannabinoids and terpenes—which all work together in synergy to provide the \"entourage effect.\" Furthermore, rather than chemical solvents, Elixinol uses CO2 to extract CBD, accessory cannabinoids and terpenes—which results in a more potent, pure and safe CBD oil.
\nFurther still, this product is very easily dosed, as the bottle specifies the miligrams of CBD per mililiter, drop or dropper-full. Most CBD products are very poorly labeled, which leads to confusion and guessing.
\nI hope this helps!
\ndrkim
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