{"componentChunkName":"component---common-build-tags-template-js","path":"/tag/anandamide/","result":{"data":{"allArticle":{"edges":[{"node":{"id":"Article_2590-markdown","title":"Eating Anandamide: The Bliss Molecule ","slug":"eating-anandamide-the-bliss-molecule","content":"The word anandamide may sound like chemistry book jargon, but its name was actually derived from the Sanskrit word for “bliss” or “joy.” Anandamide is often dubbed the “bliss molecule,” because it helps drive feelings of pleasure. As a neurotransmitter, it’s also involved in modulating memory, motivation and appetite, among other functions.\r\n\r\nFOLLOW US ON [FACEBOOK](https://www.facebook.com/pg/hellomdcompany/posts/) & [INSTAGRAM](https://www.instagram.com/hellomd_com/?hl=en)\r\n\r\n### The Connection Between Anandamide & Cannabis\r\n\r\nAnandamide was [one of the first endocannabinoids](https://emedicine.medscape.com/article/1361971-overview#showall) discovered by scientists. What makes anandamide especially unique is that it interacts with the same endocannabinoid receptors that the tetrahydrocannabinol (THC) in cannabis does. This is why some folks are able to experience feelings of euphoria and contentment when consuming THC.\r\n\r\nRELATED: [WHEN MARIJUANA MAKES YOU FEEL ANXIOUS](https://www.hellomd.com/health-wellness/59a6d4c3d651df274bd05e93/when-marijuana-makes-you-feel-anxious)\r\n\r\nEven though THC and anandamide bind to the same receptors, [anandamide is a much more fragile molecule](http://antoine.frostburg.edu/chem/senese/101/features/anandamide.shtml). After it’s produced in the brain, anandamide is quickly broken down into other compounds by an enzyme called fatty acid amide hydrolase (FAAH). The slower FAAH works, the longer anandamide stays in the body—and the longer it promotes the blissful feeling it’s named for. This chemical pathway is of major interest to scientists, who think that it may lead to treatments for disorders that involve the nervous system, like anxiety.\r\n\r\nWhat’s more, anandamide has been discovered in two foods: chocolate and black truffles.\r\n\r\n### Anandamide May Be One Reason Chocolate Is so Craveable\r\n\r\nChocolate contains more than 300 compounds, including anandamide. While sugar is mostly responsible for making chocolate delicious, scientists think these other compounds, such as caffeine and the stimulant theobromine, also enhance the satisfaction we get when we eat it.\r\n\r\nAn often-cited study found that [chocolate not only contains small amounts of anandamide](https://escholarship.org/uc/item/2kk1604c), but two other compounds that slow down its breakdown, which in theory would allow anandamide to circulate longer in the system.\r\n\r\nResearchers found anandamide in cocoa solids, which give dark chocolate its intense flavor. This suggests that the darker the chocolate, the higher the likelihood that it contains anandamide. Milk chocolate, on the other hand, is usually made with a much lower percentage of cocoa solids.\r\n\r\nIf you’ve ever wondered how to choose dark chocolate with the right percentage of cacao, check out this [handy buying guide](https://greatist.com/eat/cacao-percentages-in-chocolate). And consider applying what you’ve learned the next time you shop for a chocolate-covered cannabis edible.\r\n\r\n### Black Truffles Also Contain Anandamide\r\n\r\nThe winter [black truffle also contains anandamide](https://www.sciencedirect.com/science/article/abs/pii/S0031942214004956). Initially, this discovery puzzled researchers. Truffles don’t contain endocannabinoid receptors, so why would they need to produce anandamide?\r\n\r\nThey theorized that it might be because of [evolution](https://blogs.scientificamerican.com/food-matters/black-truffles-the-other-magic-mushroom/). Certain animals, like pigs and dogs, have endocannabinoid receptors. The anandamide could provide a positive reward to the animals that eat the truffles, encouraging them to seek out more and spread the spores.\r\n\r\nIt’s no secret that truffles carry a hefty price tag. (An ounce of black truffles will set you back at least $100.) So unless you have access to a truffle discount, there may be more cost-efficient ways to feel a little bliss.\r\n\r\n### Heads Up: Too Much Anandamide May Have a Downside\r\n\r\nWhile anandamide is best known for promoting bliss, research done on mice suggests that it’s also involved in [stimulating the appetite](https://www.ncbi.nlm.nih.gov/pubmed/11704633). In fact, some researchers think that the entire endocannabinoid system, including anandamide, may play an important role in the [development of obesity](https://www.nature.com/articles/0802250).\r\n\r\nAs more research is done on endocannabinoids, it’ll be interesting to find out how people can harness the power of anandamide, and if you can really feel its blissful effects from eating certain foods. In the meantime, you can always count on a little chocolate to boost your mood.\r\n\r\nPhoto credit: [Charisse Kenion](https://unsplash.com/@charissek)\r\n\r\nIf you’re new to cannabis and want to learn more, take a look at our [Cannabis 101](https://www.hellomd.com/health-wellness/cannabis-101-your-quick-guide-to-medical-marijuana) post. [HelloMD](https://www.hellomd.com/) can help you get your medical marijuana recommendation; it's easy, private and 100% online.  ","image":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.36986301369863,"src":"/static/7fa84992a405be5f53b54f38a3b42856/14b42/2dbbc6d208290091f526a6785a235853.jpg","srcSet":"/static/7fa84992a405be5f53b54f38a3b42856/f836f/2dbbc6d208290091f526a6785a235853.jpg 200w,\n/static/7fa84992a405be5f53b54f38a3b42856/2244e/2dbbc6d208290091f526a6785a235853.jpg 400w,\n/static/7fa84992a405be5f53b54f38a3b42856/14b42/2dbbc6d208290091f526a6785a235853.jpg 800w,\n/static/7fa84992a405be5f53b54f38a3b42856/47498/2dbbc6d208290091f526a6785a235853.jpg 1200w,\n/static/7fa84992a405be5f53b54f38a3b42856/0e329/2dbbc6d208290091f526a6785a235853.jpg 1600w,\n/static/7fa84992a405be5f53b54f38a3b42856/b2131/2dbbc6d208290091f526a6785a235853.jpg 3000w","srcWebp":"/static/7fa84992a405be5f53b54f38a3b42856/58556/2dbbc6d208290091f526a6785a235853.webp","srcSetWebp":"/static/7fa84992a405be5f53b54f38a3b42856/61e93/2dbbc6d208290091f526a6785a235853.webp 200w,\n/static/7fa84992a405be5f53b54f38a3b42856/1f5c5/2dbbc6d208290091f526a6785a235853.webp 400w,\n/static/7fa84992a405be5f53b54f38a3b42856/58556/2dbbc6d208290091f526a6785a235853.webp 800w,\n/static/7fa84992a405be5f53b54f38a3b42856/99238/2dbbc6d208290091f526a6785a235853.webp 1200w,\n/static/7fa84992a405be5f53b54f38a3b42856/7c22d/2dbbc6d208290091f526a6785a235853.webp 1600w,\n/static/7fa84992a405be5f53b54f38a3b42856/ab9f8/2dbbc6d208290091f526a6785a235853.webp 3000w","sizes":"(max-width: 800px) 100vw, 800px"}}}}},{"node":{"id":"Article_2317-markdown","title":"Is Cannabis Less Effective During Your Period?","slug":"is-cannabis-less-effective-during-your-period","content":"Cannabis has proven to be effective in managing and relieving pain. As such, it makes sense that [cannabis may also bring relief to women suffering from cramps, back pain, mood fluctuations and insomnia associated with their periods](https://www.hellomd.com/health-wellness/55a4121d38323000065b0000/medical-marijuana-may-alleviate-symptoms-associated-with-pms). \n\nThat said, brands are introducing products for women suffering from PMS and dysmenorrhea, or painful periods. Whether it’s cannabis-infused suppositories, bath salts intended to ease cramping, or a topical to soothe back or stomach pain, cannabis products have gained in popularity as a means of relieving the pain and discomfort that often comes with that time of the month.\n\nFOLLOW US ON [FACEBOOK](https://www.facebook.com/pg/hellomdcompany/posts/) & [INSTAGRAM](https://www.instagram.com/hellomd_com/?hl=en)\n\nIf you’ve ever tried using cannabis just before or during your period, you may find that you need more cannabis than usual to achieve the same effects. You ingest the same amount as you did the week prior to your premenstrual week, but somehow it doesn’t get the job done.\n\nWhy is this the case? Well, it seems estrogen may have something to do with it. In a study by Washington State University, researchers found that [female rats were 30% more likely to experience pain relief than male rats when their estrogen levels were at their peak](https://www.upi.com/Science_News/2014/09/03/Females-are-more-sensitive-to-cannabis-researchers-say/1921409778270/). Estrogen is at its highest during ovulation; it then takes a big dip during your premenstrual week and stays low throughout your period.\n\nRELATED: [MARIJUANA BRINGS RELIEF TO WOMEN SUFFERING FROM MENSTRUAL CRAMPS](https://www.hellomd.com/health-wellness/55dcd66a3961660006470000/marijuana-brings-relief-to-women-suffering-from-pms-symptoms)\n\n### How Estrogen Affects THC\n\nEstrogen, a hormone most associated with a female’s menstrual cycle, has a unique relationship with cannabinoids. Cannabinoids are chemical compounds found in cannabis and occur naturally in our bodies. We have an entire system, [the endocannabinoid system](https://www.hellomd.com/health-wellness/5751cbd970410e000b00003a/what-is-the-endocannabinoid-system), designed to process cannabinoids and help regulate many of our biological processes, from sleeping and immune function to appetite, pain management and more.\n\nWhen we consume cannabis, estrogen helps break down the THC, or the cannabinoid in cannabis that makes us feel high, into a more potent chemical compound for our bodies to absorb. This is great when our estrogen levels are high throughout our monthly cycle. High levels of estrogen make it easier for the body to process THC efficiently, allowing a smaller amount of cannabis to be more effective. \n\nUnfortunately, our period comes when estrogen levels are at their lowest. That means there’s less estrogen available in your body to efficiently break down THC, so you may find yourself consuming more cannabis than usual to achieve the same results. \n\n### How Estrogen Affects Endocannabinoids\n\nEstrogen has another very special relationship with a cannabinoid our body naturally produces: anandamide. Anandamide is an endocannabinoid that reduces the symptoms of anxiety and depression, helping us feel more calm and euphoric. Our bodies also naturally produce anandamide’s enemy: fatty acid amide hydrolase (FAAH). \n\nFAAH is an enzyme that breaks down anandamide, the bliss molecule. But anandamide finds protection in estrogen, which makes it harder for FAAH to break down anandamide in the body. When estrogen levels are low, like they are just before and during your period, FAAH is freer to break down anandamide; this makes us more susceptible to depression, anxiety and mood swings. \n\n### Cannabis Solutions During Your Period\n\nLuckily, there are some pretty clear ways to battle the lowered effectiveness of cannabis just before and during our periods. The first, and perhaps most obvious, is increasing your cannabis intake when that dreaded week of the month comes around. With more product options available than ever before, you can keep your cannabis routine fresh and new. If you’re not keen on smoking cannabis, try dosing with a tincture or consuming a marijuana edible. Or look into a product from one of the many female-run cannabis businesses—such as Moxie Meds—that make options specifically for easing period pain. \n\nAnother option is mixing high-CBD products into your cannabis routine. CBD is a cannabinoid found in cannabis that helps block FAAH from breaking down anandamide, just as estrogen does. Remember, anandamide helps us feel good by alleviating anxiety and depression. When your estrogen levels are low during your period, it may help to supplement your system with more CBD. The CBD will do the work estrogen usually does, helping to regulate your mood and relieve inflammation. \n\nPhoto credit: [@entersge](https://unsplash.com/@entersge)\n\nIf you’re new to cannabis and want to learn more, take a look at our [Cannabis 101](https://www.hellomd.com/health-wellness/cannabis-101-your-quick-guide-to-medical-marijuana) post. [HelloMD](https://www.hellomd.com/) can help you get your medical marijuana recommendation; it's easy, private and 100% online. ","image":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.3793103448275863,"src":"/static/0b17ac3213dc649eb31e76ae074c5942/14b42/6ee312cfa8c662cc0d2ebb0ad8e0468e.jpg","srcSet":"/static/0b17ac3213dc649eb31e76ae074c5942/f836f/6ee312cfa8c662cc0d2ebb0ad8e0468e.jpg 200w,\n/static/0b17ac3213dc649eb31e76ae074c5942/2244e/6ee312cfa8c662cc0d2ebb0ad8e0468e.jpg 400w,\n/static/0b17ac3213dc649eb31e76ae074c5942/14b42/6ee312cfa8c662cc0d2ebb0ad8e0468e.jpg 800w,\n/static/0b17ac3213dc649eb31e76ae074c5942/47498/6ee312cfa8c662cc0d2ebb0ad8e0468e.jpg 1200w,\n/static/0b17ac3213dc649eb31e76ae074c5942/56abc/6ee312cfa8c662cc0d2ebb0ad8e0468e.jpg 1408w","srcWebp":"/static/0b17ac3213dc649eb31e76ae074c5942/58556/6ee312cfa8c662cc0d2ebb0ad8e0468e.webp","srcSetWebp":"/static/0b17ac3213dc649eb31e76ae074c5942/61e93/6ee312cfa8c662cc0d2ebb0ad8e0468e.webp 200w,\n/static/0b17ac3213dc649eb31e76ae074c5942/1f5c5/6ee312cfa8c662cc0d2ebb0ad8e0468e.webp 400w,\n/static/0b17ac3213dc649eb31e76ae074c5942/58556/6ee312cfa8c662cc0d2ebb0ad8e0468e.webp 800w,\n/static/0b17ac3213dc649eb31e76ae074c5942/99238/6ee312cfa8c662cc0d2ebb0ad8e0468e.webp 1200w,\n/static/0b17ac3213dc649eb31e76ae074c5942/770c1/6ee312cfa8c662cc0d2ebb0ad8e0468e.webp 1408w","sizes":"(max-width: 800px) 100vw, 800px"}}}}},{"node":{"id":"Article_2271-markdown","title":"When Marijuana Makes You Feel Anxious ","slug":"when-marijuana-makes-you-feel-anxious","content":"The main reason many people use marijuana is to experience that relaxing euphoric “high” that drives away stress and anxiety. But for some, cannabis has the opposite effect, triggering the very feelings of anxiety, nervousness and irritability that it’s supposed to relieve. Although these reactions are entirely contradictory, both are also entirely natural—and they can be explained by the complex responses of the body’s own vast network of cannabis receptors, the endocannabinoid system.  \r\n\r\nFOLLOW US ON [FACEBOOK](https://www.facebook.com/pg/hellomdcompany/posts/) & [INSTAGRAM](https://www.instagram.com/hellomd_com/?hl=en)\r\n\r\n### The Endocannabinoid System\r\n\r\nHumanity’s relationship with marijuana is a long one, with records documenting its medicinal uses some 4,700 years ago. And the connection is far more ancient than that.  The human body is home to an [extensive network of cannabinoid receptor](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/)\r\n that are primed to respond to chemicals bearing a close resemblance to THC, one of the many active compounds in cannabis.  \r\n\r\nRELATED: [WHY DOES CANNABIS MAKE YOU FEEL GOOD?](https://www.hellomd.com/health-wellness/582b86cce686fc000c657034/why-does-cannabis-make-you-feel-good)\r\n\r\nThis system, called [the endocannabinoid receptor system, wasn’t discovered\r\nuntil the early 1990s](http://www.beyondthc.com/wp-content/uploads/2012/07/eCBSystemLee.pdf)—but research since then has shown that the EC system plays a role in just about every function of the human body. \r\n\r\nEndocannabinoid receptors occur in the central nervous system, the peripheral nervous system and areas of the brain responsible for higher order functions, such as the neocortex, hippocampus, cerebellum and hypothalamus. These receptors are also present in just about every organ, as well as the connective tissues and blood vessels.  \r\n\r\nAlthough research continues to reveal new discoveries about the functions of the endocannabinoid system, it’s clear that this system is involved with immune responses, pain modulation, mood and controlling inflammation. Activation of some parts of the EC system can also stimulate the growth of neural cells and slow the growth of cancer cells.  \r\n\r\nLike other receptor networks in the body, the EC system functions when a cannabinoid receptor is activated by a matching molecule, like a key fitting into a lock. So far, two cannabinoid receptors have been identified, and they respond in different ways. CB1, found mainly in the central nervous system, is responsible for psychoactive responses such as memory, mood and cognition, and CB2, which occurs primarily in the tissues, organs and peripheral nervous system, tends to regulate immune responses.\r\n\r\nThese receptors can be activated by the body’s own cannabinoid-like chemicals—or from consuming cannabis in any of its many forms. But not everyone’s endocannabinoid system is the same. Certain genes control the expression of neurotransmitters in the EC system, and variations in those genes can cause differences in how (and how much) those neurotransmitters are expressed.\r\n\r\n### Anandamide: The “Bliss Molecule”\r\n\r\nAnandamide is one of those neurotransmitters—an endocannabinoid that binds to the same C1 cannabinoid receptors as THC, the psychoactive ingredient in marijuana. Anandamide, which gets its name from ananda, the Sanskrit word for bliss, has been called the “bliss molecule” for its key feature of [promoting a state of happiness and contentment](https://www.cannabis.info/en/what-is-anandamide-how-does-it-help-marijuana-users). \r\n\r\nBut anandamide does much more. It also plays an important role in supporting memory, thought and coordination, as well as in suppressing pain and slowing the proliferation of cancer cells. It’s also responsible for that exercise-induced euphoria known as “runner’s high.”\r\n\r\nAnandamide levels are not fixed, and it’s possible to increase them with activities like exercise and intense creative work, which stimulate the release of endorphins, serotonin and dopamine, neurotransmitters that are related to pleasure and reward. Eating chocolate boosts anandamide levels, too, which can explain why so many people turn to chocolate to soothe disappointment and broken hearts. And the highly expensive black truffle contains anandamide all on its own. But because anandamide is so similar to THC, using cannabis is also a way to trigger its calming, mood-boosting properties. For some people, though, other factors interfere with that pleasurable effect.\r\n\r\n### FAAH – Is It the “Feel-Good Gene”?\r\n\r\nAnandamide is a fragile neurotransmitter with a relatively short life. It’s regulated by a gene that produces an enzyme called [fatty acid amide hydrolase, or FAAH](https://www.ncbi.nlm.nih.gov/gene/2166), which is responsible for breaking it down. In the presence of higher levels of FAAH, more anandamide is broken down, leaving the system vulnerable to feelings of anxiety and depression. When that happens, the brain is more inclined to respond to the calming effects of cannabis.\r\n\r\nBut when less FAAH is available, more anandamide can continue to circulate in the brain. Those levels can fluctuate for a variety of reasons, but some people have a variant of the FAAH gene that allows higher levels of anandamide to circulate in the brain, causing more overall feelings of happiness and less inclination to recall frightening or disturbing events.  \r\n\r\nIn a recent New York Times article, physician Richard Friedman called [FAAH the “feel-good gene.”](https://www.nytimes.com/2015/03/08/opinion/sunday/the-feel-good-gene.html?mcubz=0) According to Friedman, people with this genetic variation tend to feel naturally more upbeat and calm, so that they don’t typically respond to the relaxing effects of THC in cannabis. On the other hand, people with the “normal” FAAH gene—about 80 percent of U.S. adults of European descent—have lower levels of anandamide, so for these people cannabis is more likely to have a pleasurable effect.\r\n\r\nThe existence of a [\"feel-good gene” that keeps anandamide levels high in some people remains controversial](https://blogs.scientificamerican.com/cross-check/n-y-times-hype-of-8220-feel-good-gene-8221-makes-me-feel-bad/). But it may help to explain how the relationship between FAAH levels and anandamide can affect the way a user responds to cannabis.  \r\n\r\nAnandamide levels aren’t the only factor contributing to feelings of anxiety and nervousness when using cannabis. Strains with higher levels of THC can overwhelm the system, too—and some people may feel those anxious symptoms at one time but not at others. But the complex play of cannabis and the body’s own endocannabinoid system can have unexpected results—and the path to feeling good can leave some cannabis users feeling bad instead.\r\n\r\nIf you're new to cannabis and want to learn more, take a look at our [Cannabis 101](https://www.hellomd.com/health-wellness/cannabis-101-your-quick-guide-to-medical-marijuana) post. [HelloMD](https://www.hellomd.com/) can help you get your medical marijuana recommendation; it's 100% online, private and efficient.  ","image":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.3333333333333333,"src":"/static/034c60c1a04e2e20a868933701449f01/14b42/e25347d5b444ce1de77673d48a480e13.jpg","srcSet":"/static/034c60c1a04e2e20a868933701449f01/f836f/e25347d5b444ce1de77673d48a480e13.jpg 200w,\n/static/034c60c1a04e2e20a868933701449f01/2244e/e25347d5b444ce1de77673d48a480e13.jpg 400w,\n/static/034c60c1a04e2e20a868933701449f01/14b42/e25347d5b444ce1de77673d48a480e13.jpg 800w,\n/static/034c60c1a04e2e20a868933701449f01/47498/e25347d5b444ce1de77673d48a480e13.jpg 1200w,\n/static/034c60c1a04e2e20a868933701449f01/54ac5/e25347d5b444ce1de77673d48a480e13.jpg 1365w","srcWebp":"/static/034c60c1a04e2e20a868933701449f01/58556/e25347d5b444ce1de77673d48a480e13.webp","srcSetWebp":"/static/034c60c1a04e2e20a868933701449f01/61e93/e25347d5b444ce1de77673d48a480e13.webp 200w,\n/static/034c60c1a04e2e20a868933701449f01/1f5c5/e25347d5b444ce1de77673d48a480e13.webp 400w,\n/static/034c60c1a04e2e20a868933701449f01/58556/e25347d5b444ce1de77673d48a480e13.webp 800w,\n/static/034c60c1a04e2e20a868933701449f01/99238/e25347d5b444ce1de77673d48a480e13.webp 1200w,\n/static/034c60c1a04e2e20a868933701449f01/5e0b8/e25347d5b444ce1de77673d48a480e13.webp 1365w","sizes":"(max-width: 800px) 100vw, 800px"}}}}},{"node":{"id":"Article_2128-markdown","title":"Why Does Cannabis Make You Feel Good?","slug":"why-does-cannabis-make-you-feel-good","content":"It was long believed that the “high” associated with cannabis was caused by a flood of dopamine released by the consumption of tetrahydrocannabinol (THC). This theory has been largely discredited, though it's still believed that cannabinoid receptors in the body are closely linked to the body's reward system. Cannabis, when compared to drugs like amphetamines and cocaine, only produces a moderate amount of dopamine. THC does, however, work on the same receptors as our bodies’ naturally occurring, pleasure-inducing endocannabinoid, anandamide. \r\n\r\nFOLLOW US ON [FACEBOOK](https://www.facebook.com/pg/hellomdcompany/posts/) & [INSTAGRAM](https://www.instagram.com/hellomd_com/?hl=en)\r\n\r\n### Cannabis's Connection to Anandamide, the Feel-Good Molecule\r\n\r\nAnandamide is a neurotransmitter that's believed to be the true cause of the euphoria related to cannabis. Anandamide, which is one of the body's natural endocannabinoids, is known to produce joy and happiness. It also plays a role in memory, motivation, pain, appetite and fertility. It's the binding of anandamide with the CB1 receptor that produces the “feel good” effect that is similar to that associated with cannabis usage. \r\n\r\nMeanwhile, a study published in 2014 in the journal *Transitional Medicine* found that [anandamide can even affect the growth of breast cancer cells](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140423/). The study found that anandamide inhibits pro-angiogenic factors, which provides its anti-tumor efficacy. Anandamide, which is very fragile, also has anti-anxiety and anti-depressant properties. \r\n\r\nTHC in cannabis works on the same receptors that anandamide does, allowing it to stimulate happy and euphoric feelings in a similar way. THC works to supplement the body's internally produced anandamide. This is why it can help boost people's moods. Cannabis, however, doesn't always have joy-producing effects on people. Some folks may experience negative effects from using cannabis—this effect is also linked to anandamide. \r\n\r\n### Why Do Some Folks Feel Anxious After Using Cannabis?\r\n\r\nFAAH, also known as fatty acid amide hydrolase, is a naturally occurring molecule in the body that deactivates anandamide. People are genetically predisposed to produce more or less FAAH, which changes the levels of anandamide in their body.\r\n\r\nFolks with less FAAH, who naturally have more anandamide, tend to have more anxiety-producing effects from cannabis. This is because their increased levels of anandamide quicken the biphasic effects of cannabis. Since they already have higher levels of anandamide binding to their CB1 receptors, they can easily be overwhelmed by smaller levels of THC, which binds to the same receptors. \r\n\r\nRELATED: [WHEN MARIJUANA MAKES YOU FEEL ANXIOUS](https://www.hellomd.com/health-wellness/59a6d4c3d651df274bd05e93/when-marijuana-makes-you-feel-anxious)\r\n\r\n### Anandamide, Chocolate and the Runner's High\r\n\r\nCannabis isn't the only thing that can stimulate anandamide and boost your mood. Chocolate, which contains theobromine, is believed to cause the brain to produce more anandamide. Theobromine is a relaxant that is related to caffeine that is believed to stimulate anandamide production in the body. Chocolate also contains molecules that slow the breakdown of anandamide. The stimulation of anandamide is believed to be one of the main reasons why chocolate is one of the most commonly craved foods. Other foods, including truffles, parsley, tea and celery, also contain anandamide or stimulate its production. Exercise also can produce anandamide. The “runner's high” associated with working out is actually related to increased anandamide production, rather than just by a flood of endorphins as previously thought.\r\n\r\n_____________________________________________________________________\r\n\r\nIf you're new to cannabis and want to learn more, take a look at our [Cannabis 101](https://www.hellomd.com/health-wellness/cannabis-101-your-quick-guide-to-medical-marijuana) post. [HelloMD](https://www.hellomd.com/) can help you get your medical marijuana recommendation; it's 100% online, private and efficient.","image":{"childImageSharp":{"fluid":{"base64":"data:image/png;base64,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","aspectRatio":1.3333333333333333,"src":"/static/c46e122669688ba957a90882975cbc15/ee604/359519734b2b62762faf609ec7fdd8da.png","srcSet":"/static/c46e122669688ba957a90882975cbc15/69585/359519734b2b62762faf609ec7fdd8da.png 200w,\n/static/c46e122669688ba957a90882975cbc15/497c6/359519734b2b62762faf609ec7fdd8da.png 400w,\n/static/c46e122669688ba957a90882975cbc15/ee604/359519734b2b62762faf609ec7fdd8da.png 800w,\n/static/c46e122669688ba957a90882975cbc15/4c5c8/359519734b2b62762faf609ec7fdd8da.png 1004w","srcWebp":"/static/c46e122669688ba957a90882975cbc15/58556/359519734b2b62762faf609ec7fdd8da.webp","srcSetWebp":"/static/c46e122669688ba957a90882975cbc15/61e93/359519734b2b62762faf609ec7fdd8da.webp 200w,\n/static/c46e122669688ba957a90882975cbc15/1f5c5/359519734b2b62762faf609ec7fdd8da.webp 400w,\n/static/c46e122669688ba957a90882975cbc15/58556/359519734b2b62762faf609ec7fdd8da.webp 800w,\n/static/c46e122669688ba957a90882975cbc15/eddbc/359519734b2b62762faf609ec7fdd8da.webp 1004w","sizes":"(max-width: 800px) 100vw, 800px"}}}}},{"node":{"id":"Article_2129-markdown","title":"America's Newest Addiction: Anxiety Medication","slug":"americas-newest-addiction-anxiety-medication","content":"### We Are Anxious People\r\n\r\nBenzodiazepines are anti-anxiety medications, like Xanax and Valium, that are prescribed to patients to help control various anxiety conditions. 5.2% of adults in the United States take benzodiazepines according to a [2015 JAMA Psychiatry study](http://archpsyc.jamanetwork.com/article.aspx?articleid=2019955). \r\n\r\nThough there are adults of all ages who take benzodiazepines, rates of use increase with older age. 8.7% of people between the ages of 65 and 80 years old take benzodiazepines and it is believed the increase in use is linked to more stressful events that occur later in life. This is particularly problematic because benzodiazepine use is often linked to grogginess, which can cause an increase in falls and other accidents. \r\n\r\nThe use of benzodiazepines is also overall twice as prevalent in women than it is in men. A quarter of people taking benzodiazepines reported long term usage, which is not what the medications were designed for. \r\n\r\n### Long Term Risks & Stats\r\n\r\nThe risks of using these medications long term often outweighs the benefits and can lead to an increase in tolerance that requires an inflation in dose. Benzodiazepines are often used in association with opioids, which can lead to even more complications. Between the [years](http://fox13now.com/2016/09/06/rise-in-middle-aged-american-women-deaths-attributed-to-opioid-anti-anxiety-drug-overdoses/) of 1999 and 2004, the number of middle aged caucasian woman who died from overdoses went up by 400%. \r\n\r\nBenzodiazepines were responsible for 1/3 of the 54,000 deaths that were caused by overdoses. Caucasian women were far more likely to be prescribed a mix of opioids and benzodiazepines, which leads to an increase in these statistics. It is also believed that the high number of opioid and benzodiazepine prescriptions for women has lead to an increase in overall deaths of women. \r\n\r\nMany women who have committed suicide also have either benzodiazepines, opioids, or both, in their system during the time of death and it is believed that the inhibition they both cause leads to an increase in female death rates. Roughly 20% of people with anxiety disorders also have substance abuse disorders, meaning that the prescriptions of benzodiazepines have to be monitored closely, and they often are not.\r\n\r\n### Cannabis as an Alternative\r\n\r\nCannabis can be an effective alternative to benzodiazepines to help with anxiety. Cannabis has been used to treat anxiety and depression for more than 400 years. Though THC can cause some increase in anxiety because of its psychoactive properties, CBD can be extremely effective at reducing anxiety. THC can be balanced with CBD in particular cannabis strains which can work to decrease anxiety, though overall, high CBD and low THC strains are most effective at reducing anxiety. \r\n\r\nA [study](http://www.ncbi.nlm.nih.gov/pubmed/21307846) completed in 2011 provided a breakthrough into how CBD could help patients with Social Anxiety Disorder. 24 patients with SAD, who had never been treated, were either given a placebo or a dose of CBD before a public speaking test. Researchers monitored physiological measures to determine levels of anxiety during the public speaking test and found a significant decrease in anxiety levels among patients who received CBD. The physiological results were consistent with the self-surveys that subjects completed after the test regarding their levels of anxiety. \r\n\r\nAnother 2011 study that was published in the Journal of Psychopharmacology that monitored the cerebral blood flow of participants after a CBD treatment. The patients in the study all had Social Anxiety Disorder. The study was limited and only included 10 participants, but it showed that patients treated with CBD experienced a decreased level of social anxiety after receiving the treatment, compared to those who took a placebo. \r\n\r\nA Vanderbilt [study](https://www.medicaljane.com/2014/08/11/study-cannabinoid-therapies-may-help-treat-stress-induced-anxiety-disorders/) published in Transitional Psychiatry looked at the role of anandamide in anxiety. Anandamide is an endocannabinoid that occurs naturally in the body, and it works to treat stress induced anxiety. \r\n\r\nCannabinoids from cannabis work on the body's endocannabinoid system in a similar way to endocannabinoids like anandamide. CBD can decrease production of fatty acid amide hydrolase, which is an enzyme that degrades naturally occurring anandamide. CBD can work to preserve anandamide, helping the body to decrease anxiety by itself. \r\n\r\nAll of these studies show that CBD has great efficacy at treating anxiety when administered during clinical trials. All of these studies were completed on people and show how marijuana that features high levels of CBD can be self administered by patients could help reduce various anxiety conditions. CBD not only works to decrease anxiety, but also aids the body's natural processes for reducing anxiety. \r\n\r\nDo you have questions about anxiety medications and cannabis? Ask a question in [HelloMD's new Answers](https://www.hellomd.com/) feature. \r\n\r\nIf you are new to cannabis and want to learn more, take a look at our [Cannabis 101](https://www.hellomd.com/health-wellness/cannabis-101-your-quick-guide-to-medical-marijuana) post. [HelloMD](https://www.hellomd.com/) can help you get your medical marijuana recommendation; it's 100% online, private and efficient.","image":{"childImageSharp":{"fluid":{"base64":"data:image/jpeg;base64,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","aspectRatio":1.3333333333333333,"src":"/static/8c6f14e299d1f6d1b89b076622ccfa16/14b42/a3460082b21a5f2bb04eae7981348c38.jpg","srcSet":"/static/8c6f14e299d1f6d1b89b076622ccfa16/f836f/a3460082b21a5f2bb04eae7981348c38.jpg 200w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/2244e/a3460082b21a5f2bb04eae7981348c38.jpg 400w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/14b42/a3460082b21a5f2bb04eae7981348c38.jpg 800w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/47498/a3460082b21a5f2bb04eae7981348c38.jpg 1200w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/54ac5/a3460082b21a5f2bb04eae7981348c38.jpg 1365w","srcWebp":"/static/8c6f14e299d1f6d1b89b076622ccfa16/58556/a3460082b21a5f2bb04eae7981348c38.webp","srcSetWebp":"/static/8c6f14e299d1f6d1b89b076622ccfa16/61e93/a3460082b21a5f2bb04eae7981348c38.webp 200w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/1f5c5/a3460082b21a5f2bb04eae7981348c38.webp 400w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/58556/a3460082b21a5f2bb04eae7981348c38.webp 800w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/99238/a3460082b21a5f2bb04eae7981348c38.webp 1200w,\n/static/8c6f14e299d1f6d1b89b076622ccfa16/5e0b8/a3460082b21a5f2bb04eae7981348c38.webp 1365w","sizes":"(max-width: 800px) 100vw, 800px"}}}}}]}},"pageContext":{"limit":12,"skip":0,"numPages":1,"currentPage":1,"id":4943,"name":"Anandamide","slug":"anandamide","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}