{"componentChunkName":"component---common-build-tags-template-js","path":"/tag/endocannabinoids/","result":{"data":{"allArticle":{"edges":[{"node":{"id":"Article_2158-markdown","title":"Endocannabinoid System & Habit Forming","slug":"endocannabinoid-system-and-habit-forming","content":"### How the Endocannabinoid System Relates to Our Habits\r\n\r\nA recent study published in _Neuron_, a prominent neuroscience journal, showed a promising connection between habit forming and the endocannabinoid system (ECS). The research was led by Christina Gremel, an assistant professor of physiology at the University of California San Diego. The study showed that endocannabinoids, neurochemicals in our body that are similar to cannabinoids found in cannabis, allow for habit to take control of our body's action. This redirects our body from a goal-directed action to a habit, which we have preformed many times, such as brushing our teeth. It was already known that the ECS played a role in many parts of our bodies inner workings, but this study shows a new breakthrough in how important the endocannabinoid system is to our overall body function. \r\n\r\n### Orbital Frontal Cortex & Habit or Goal-Directed Action\r\n\r\nEarlier research by Gremel focused on the orbital frontal cortex (OFC), which is important for relaying information related to goal-directed action. When researchers increased the number of output neurons in the OFC using optogenetics, flashes of light that turn on and off receptors in the brain, they found that goal-directed action increased. When they decreased neuron outputs, the OFC was subdued and habit took over. This previous research served as a base for the understanding of how the OFC is connected to habit and goal-directed action, which was an important component in the study that showed the connection between the ECS and habit formation.\r\n\r\n### The Endocannabinoid System and Habit Formation\r\n\r\nThe study related to the ECS was conducted using trained mice, which pushed a lever for a food reward. They placed the mice in two different environments, one that was goal-directed and one that was habitual. The mice were able to switch between the two environments with relative ease, much like a human can switch between habitual action and a new task they set out to do. For example, the difference between the habit of getting home or the goal-directed action of getting to a new location not previously known. The researchers hypothesized that cannabinoids may be responsible for quieting the OFC, because they're known to reduce neuron activity in general, allowing habit to take over in the brain. \r\n\r\nTo test this hypothesis, researchers deleted the CB1 receptor in the orbital frontal cortex-to-striatum pathway. Mice missing the CB1 receptors weren't able to form habits, showing the critical connection between the ECS and the neurochemicals that travel along the pathway. It can be concluded from this study that without the ECS stimulated by internal cannabinoids, the consequences could be great, because they couldn't form habits.\r\n\r\n“We need a balance between habitual and goal-directed actions. For everyday function, we need to be able to make routine actions quickly and efficiently, and habits serve this purpose,” said lead researcher Gremel. “However, we also encounter changing circumstances, and need the capacity to ‘break habits’ and perform a goal-directed action based on updated information. When we can’t, there can be devastating consequences.”\r\n\r\nThis study could prompt exploration into a new therapeutic use for marijuana for people with OCD or addiction problems. If the endocannabinoid system is deeply rooted in habit forming, and being able to break from habits based on a goal-directed action, it could aid in decreasing over-reliance on a particular habit. The body's own endocannabinoid system may need to be treated in some way to restore the ability to shift from habits to goal-directed action. \r\n\r\n[Photo Credit](https://www.flickr.com/photos/patricksavalle/9117978909/in/photolist-eTJ2sV-pzrtM8-hzDFXw-zHZNob-hzDvmR-r8EjBC-AoqtoW-nShRRP-q9g9fG-qM2oUL-rypYCT-hw9SCx-bwrdqi-iHnwCf-pKQRmF-ACJdCQ-c6gErf-pbhqCB-ndE9T1-hw9ZV1-9mcPgh-ADQ8i9-ADQeTy-oTN878-c2aXWU-aMZ8qp-c6a5fq-8cgqdh-ACJgYN-ADQaSY-zJ9f42-q7FZcA-zHZMes-qHeAdF-qdWLSN-qsKcw1-pJ4zEP-AoqiBb-nm3aYa-icvBja-Gyvo55-icvahc-icvaKB-qQ8S14-mmv9ta-ai7hLR-pb1F5v-pUhKDK-bnCSKK-ai7gQa)","image":{"childImageSharp":{"fluid":{"base64":"data:image/png;base64,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","aspectRatio":1.5151515151515151,"src":"/static/7a12497232ae98a177bc01367b4885da/ee604/b24ba8b12aa4065ebc83dbd7b7729713.png","srcSet":"/static/7a12497232ae98a177bc01367b4885da/69585/b24ba8b12aa4065ebc83dbd7b7729713.png 200w,\n/static/7a12497232ae98a177bc01367b4885da/497c6/b24ba8b12aa4065ebc83dbd7b7729713.png 400w,\n/static/7a12497232ae98a177bc01367b4885da/ee604/b24ba8b12aa4065ebc83dbd7b7729713.png 800w,\n/static/7a12497232ae98a177bc01367b4885da/3b2e7/b24ba8b12aa4065ebc83dbd7b7729713.png 1034w","srcWebp":"/static/7a12497232ae98a177bc01367b4885da/58556/b24ba8b12aa4065ebc83dbd7b7729713.webp","srcSetWebp":"/static/7a12497232ae98a177bc01367b4885da/61e93/b24ba8b12aa4065ebc83dbd7b7729713.webp 200w,\n/static/7a12497232ae98a177bc01367b4885da/1f5c5/b24ba8b12aa4065ebc83dbd7b7729713.webp 400w,\n/static/7a12497232ae98a177bc01367b4885da/58556/b24ba8b12aa4065ebc83dbd7b7729713.webp 800w,\n/static/7a12497232ae98a177bc01367b4885da/bfd1f/b24ba8b12aa4065ebc83dbd7b7729713.webp 1034w","sizes":"(max-width: 800px) 100vw, 800px"}}}}},{"node":{"id":"Article_2100-markdown","title":"What Is the Endocannabinoid System?","slug":"what-is-the-endocannabinoid-system","content":"The endocannabinoid system, the series of cannabinoid receptors throughout the human body, was named for the drug that sparked its discovery, cannabis. As researchers strove to learn more about how cannabis affected the human body, they discovered a series of cannabinoid receptors, which respond to cannabinoids produced by the body and those present in marijuana. \n\nCannabinoid receptors are found in the brain, organs, connective tissue, glands and immune cells, making them essential to the function of almost all parts of the human body. All animal species, with the exception of bugs, have an endocannabinoid system, and researchers believe it evolved approximately 600 million years ago. Though there are many gaps in the scientific knowledge of the endocannabinoid system, scientists have still gathered a lot of information on its function within the human body.\n\nThe endocannbinoid system responds to both endocannabinoids, cannabinoids produced within the body, and phyotocannabinoids, cannabinoids that are sourced from plants. There are believed to be several endocannabinoids, but the two most well understood are anandamide and 2-arachidonolyglycerol.\n\nPhytocannabinoids have mostly been identified from Cannabis sativa, but they have also been found in other medicinal herbs, such as Echinacea purpura. The most well-known cannabinoids from cannabis are THC and CBD. Cannabinoids can be psychoactive, as is the case with THC, though most cannabinoids are non-psychoactive. \n\n### The Endocannabinoid System in the Human Body\n\nScientists believe there are more cannabinoid receptors present than any other receptor in the human body. Two specific kinds of cannabinoid receptors have been identified to make up the endocannabinoid system. The CB1 receptor is normally present in the nervous system, connective tissues, gonads, glands and organs, whereas the CB2 receptor is present in the immune system and associated structures.\n\nDue to the fact that cannabinoid receptors reach into almost every part of the body, cannabinoids are integral in many different bodily functions. Cannabinoids are used in intercellular communication, and since their discovery, have helped us better understand the bridges between body and mind. \n\nCannabinoids are also crucial in the process of maintaining homeostasis within cells and the body as a whole. The endocannabinoid system regulates autophagy, a process in which the cell segregates one part of its contents to be self-digested. It's extremely important that the body maintain the correct balance of cannabinoids in order to function properly and keep the whole body healthy.\n\n“While this process keeps normal cells alive, allowing them to maintain a balance between the synthesis, degradation, and subsequent recycling of cellular products, it has a deadly effect on malignant tumor cells, causing them to consume themselves in a programmed cellular suicide. The death of cancer cells, of course, promotes homeostasis and survival at the level of the entire organism,” said Dustin Sulak, DO to Norml. \n\n### How Cannabis Works on Our Endocannabinoid System\n\nCannabinoids from marijuana can stimulate or mimic our natural cannabinoid production. When phytocannabinoids are introduced, they can cause an increase of cannabinoid receptors in the body. This increase in cannabinoid receptors can help to explain why people don't “feel” any effects the first time they take marijuana. But their heightened number of cannabinoid receptors, once they've previously introduced cannabinoids into their body, causes a more prominent effect.\n\nCannabis can work synergistically with the endocannabinoids produced inside the body to bring the body into homeostasis. Cannabis, unlike other synthetic medications, works in harmony with the body to bring it into health by obtaining equilibrium. \n\n### The Key to Many Chronic Illnesses\n\nClinical Endocannabinoid Deficiency (CECD) is believed to occur when endocannabinoid levels are found to be persistently lower than healthy control. The cause of CECD is unknown, but it is believed that an imbalance of cannabinoids could either be congenital or acquired throughout a period of time. Low endocannabinoid levels could be the cause of some chronic illnesses, rather than just a symptom. CECD is most often attributed to fibromyalgia, migraines, irritable bowel syndrome (IBS), autism spectrum disorder (ASD) and cystic fibrosis. \n\nMany sufferers of the five conditions that are thought to be attributed to CECD often feel relief when using marijuana as a medication. Cannabinoids, such as THC, have been found to inhibit serotonin release in migraine sufferers, thereby relieving symptoms.\n\nIBS is thought to be related to endocannabinoid and serotonergic signaling. Though research into the connection is limited, this connection suggests that CB receptors may be a good target in alleviating IBS-related complications.\n\nASD has been linked to dysfunctional endocannabinoid signaling. This altered endocannabinoid expression suggests that there may be scientific backing for the anecdotal reports from parents who've had success administering medical marijuana to their children with ASD.\n\nAnd finally, 2011 study suggests that chronic congenital cystic fibrosis is the result of imbalanced endocannabinoid levels, indicating that phytocannabinoids could be viable routes of treatment. \n\n### How Can Cannabis Help?\n\nThe endocannabinoid system is all about balance and equilibrium. Finding the proper treatment is unique to each individual because it involves balancing cannabinoids found in the body with those provided by medical marijuana. Most current research seems to point to success using high-THC, low-CBD strains when combatting CECD-related conditions. That said, CBD appears to be very helpful in alleviating symptoms in other conditions. \n\nAs more research is done on the endocannabinoid system in the human body, medical marijuana prescriptions can become more precise and be less of a trial-and-error process. The increase in knowledge of the benefits of medical marijuana in aiding the body's own endocannabinoid system is crucial.\n\nDoctors today don't even learn about the endocannabinoid system in medical school, which is extremely detrimental to the overall health of the population. The first textbook on medical marijuana, however, is being released on May 31, 2016, giving hope for increased learning on the endocannabinoid system. \n\nInterested in asking a question about this topic? Go to [HelloMD Answers](https://www.hellomd.com/answers) and ask one of our doctors or community. \n\nIf you're new to cannabis and want to learn more, take a look at our [Cannabis 101](https://www.hellomd.com/health-wellness/56201c206430320006bb0000/cannabis-101-your-quick-guide-to-medical-marijuana) post. [HelloMD](https://www.hellomd.com/) can help you get your medical marijuana recommendation; it's easy, private and 100% online.","image":{"childImageSharp":{"fluid":{"base64":"data:image/png;base64,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","aspectRatio":1.694915254237288,"src":"/static/768d230b0385b65850b8409cc606da0b/27625/4d822476cec6f575a6e6b373295fa8d0.png","srcSet":"/static/768d230b0385b65850b8409cc606da0b/69585/4d822476cec6f575a6e6b373295fa8d0.png 200w,\n/static/768d230b0385b65850b8409cc606da0b/497c6/4d822476cec6f575a6e6b373295fa8d0.png 400w,\n/static/768d230b0385b65850b8409cc606da0b/27625/4d822476cec6f575a6e6b373295fa8d0.png 680w","srcWebp":"/static/768d230b0385b65850b8409cc606da0b/8829b/4d822476cec6f575a6e6b373295fa8d0.webp","srcSetWebp":"/static/768d230b0385b65850b8409cc606da0b/61e93/4d822476cec6f575a6e6b373295fa8d0.webp 200w,\n/static/768d230b0385b65850b8409cc606da0b/1f5c5/4d822476cec6f575a6e6b373295fa8d0.webp 400w,\n/static/768d230b0385b65850b8409cc606da0b/8829b/4d822476cec6f575a6e6b373295fa8d0.webp 680w","sizes":"(max-width: 680px) 100vw, 680px"}}}}},{"node":{"id":"Article_2055-markdown","title":"Is Your Endocannabinoid System in Balance?","slug":"is-your-endocannabinoid-system-in-balance","content":"You balance your work with your family life, fatty foods with healthy ones, stress with\r\nhappiness. But what about your endocannabinoid system? The\r\nendocannabinoid system is a pivotal body system that impacts a multitude\r\nof other health factors and, when it's improperly balanced, it can have\r\na negative impact on your overall health. Here's what you need to know:\r\n\r\n**What Is the Endocannabinoid System?**\r\n\r\nThe endocannabinoid system (ECS) consists of a selection of highly\r\nspecialized lipids and receptors within the brain. The system acts on\r\nthe nervous system to produce things like hunger, pain, responses to\r\nstress, memory building, inflammation and muscle control. The ECS also\r\nhas a direct impact on things like sleep, muscle control, energy and\r\nmood.\r\n\r\n**Cannabinoid Receptors 101**\r\n\r\nThe ECS relies on a series of cannabinoid receptors to support its\r\nfunction. These receptors are actually cell membrane receptors that are\r\nshaped like an \"S.\" Each receptor has seven parts that are designed to\r\npermeate cell membranes, where they couple with G-proteins.\r\n\r\nThis coupling is what produces a sensation response within the human\r\nbrain. The compounds that couple with cannabinoid receptors are known as\r\n\"lipophilic,\" or \"fat-loving.\" These compounds include such naturally\r\nsynthesized compounds as endocannabinoids, phytocannabinoids (these are\r\nplant-derived compounds such as Cannabidiol, which comes from cannabis)\r\nand synthetic cannabinoids.\r\n\r\nCannabinoid receptors are broken into two separate groups: CB1 and CB2.\r\nThese groups are quite distinctly different, although they do share some\r\nsimilar traits. CB1 receptors, for example, are located predominantly in\r\nthe brain, kidneys, liver, lungs, body fat, muscle tissue, bones and\r\nheart. These receptors are responsible for processing the psychoactive\r\ntraits of THC. CB2 receptors, on the other hand, are located primarily\r\nin the immune system and bloodstream, and in lesser amounts in the gut,\r\nmuscle, bone, nervous system and liver. These receptors provide pain\r\nrelief.\r\n\r\n**Endocannabinoid Receptors and the Balance of the ECS**\r\n\r\nWhen we talk about the balance of the ECS, we're talking about the\r\npresence and activity of CB1 versus CB2 within the body. In this case,\r\nhowever, \"balance\" doesn't mean a 50/50 split between CB1 and CB2.\r\nInstead, optimal health can be achieved when people have slightly higher\r\nlevels of CB2 than they do CB1. This is because [research has\r\nshown](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267552/) that people\r\nwith high levels of CB1 suffer from conditions associated with stress\r\nand anxiety, such as paranoia, appetite loss, nausea and vomiting, pain\r\nand improper immune function.\r\n\r\nA high level of CB2, on the other hand, is associated with positive\r\neffects, such as decreased inflammation, rapid tissue reconstruction and\r\nhealing, higher metabolic function, healthier levels of insulin, and\r\nhealthy energy levels.\r\n\r\nIn light of this, researchers have been working to produce effective CB1\r\nblockers that can decrease the negative impacts of excess CB1 while\r\nhighlighting the positive aspects of CB2, such as increased metabolic\r\nfunction. These products aim to improve the symptoms associated with\r\nconditions like metabolic syndrome (such as elevated blood pressure and\r\nblood sugar, high levels of body fat, and high cholesterol levels),\r\nwhich is known to increase the likelihood of stroke, diabetes and\r\nvarious forms of heart disease.\r\n\r\nWhile more research is needed on the topic of CB1 blockers, preliminary\r\ndata has already shown that lowering CB1 levels in the body can help to\r\nreduce blood pressure and cholesterol levels, lower blood sugar, and aid\r\nin abdominal fat loss, which results in a decreased risk for conditions\r\nlike type II diabetes and heart disease.\r\n\r\n**Balancing the ECS**\r\n\r\nBefore you write it off completely, it's important to remember that CB1\r\ndoes serve an important purpose. Recent research has suggested that\r\nmaintaining the correct levels of CB1 within the body protects against\r\ndepressive symptoms and helps [lower stress in\r\nrodents](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808114/). This\r\nproves the importance of maintaining balance in the ECS.\r\n\r\nOne of the most astounding functions of the ECS is that it helps control\r\nand enhance the function of the integumentary system, which includes\r\nhair and human skin cells. When the ECS is balanced, negative skin cell\r\ngrowth and various forms of inflammation immediately decline. Because of\r\nthis, targeted manipulation of ECS balance has been posed as a treatment\r\noption for people suffering from painful or dangerous skin conditions\r\nsuch as acne, dermatitis, psoriasis, eczema and systemic sclerosis.\r\n\r\nIn addition to exploring CB1 blockers to help maintain a balance between\r\nCB1 and CB2 within the human brain, scientists are also studying the\r\nimpact of diet. Currently, there is evidence that [ample intake of\r\nomega-3s and\r\nomega-6s](http://www.nature.com/ijo/journal/v40/n1/full/ijo2015135a.html)\r\ncan support the proper function of cannabinoid receptors within the\r\nbrain.\r\n\r\n**Perfect Balance Leads to Enhanced Function**\r\n\r\nBalancing the ECS is a delicate process but, when done correctly, it can\r\nhave a marked positive effect on lives. People with excessively high CB1\r\nlevels often struggle with things like inflammation, increased risk of\r\nheart disease, obesity and diabetes. If CB1 is inhibited too much,\r\nhowever, it leads to conditions like infertility, depression and\r\ndecreased immune function. At the same time, when CB2 levels are too\r\nhigh, decreased immune function and impaired tissue healing are the\r\nresults.\r\n\r\nIn light of these findings, it's clear that, to obtain optimal health,\r\npeople must focus more strongly on building and maintaining the proper\r\nbalance between CB1 and CB2 through the responsible use of CB1 blockers\r\nand proper diet.\r\n\r\n[Photo Credit](https://www.flickr.com/photos/ionelpop/3497683677/in/photolist-6k5xuZ-aCxyQp-5s4UHq-6mALK4-6LSHuE-6NhXom-6A2H4j-7rSMrd-gqWG4G-cKkK7J-r27bTR-e7Ccs-5EXdWc-iLSRKW-6t3oND-NaD7c-9VF398-4i23w4-7qLrMY-99JBcD-4RuyQh-4Cn1S6-9AWcjM-jj8Tr-4b6B4P-6hTeA5-7GzQ2Q-4FBdtH-8es7qz-ggmxG-7ffDWk-969QLS-aTwPdT-6uAL8c-dRn1y-35tLLb-4kNKhg-9Mo2MP-exre5x-5BSWy3-966AkK-4P99b4-6JaZCt-5bF8ZX-8JA2Ux-5cY2fx-yVcAM-cSrFwG-cf4ZGG-9C5REj)","image":{"childImageSharp":{"fluid":{"base64":"data:image/png;base64,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","aspectRatio":1.5267175572519085,"src":"/static/e4bc33e90fbf073c98a68bf53b1a8b87/ee604/791a9068fcdcdc7636ab94fbe31e8b00.png","srcSet":"/static/e4bc33e90fbf073c98a68bf53b1a8b87/69585/791a9068fcdcdc7636ab94fbe31e8b00.png 200w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/497c6/791a9068fcdcdc7636ab94fbe31e8b00.png 400w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/ee604/791a9068fcdcdc7636ab94fbe31e8b00.png 800w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/f3583/791a9068fcdcdc7636ab94fbe31e8b00.png 1200w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/df997/791a9068fcdcdc7636ab94fbe31e8b00.png 1204w","srcWebp":"/static/e4bc33e90fbf073c98a68bf53b1a8b87/58556/791a9068fcdcdc7636ab94fbe31e8b00.webp","srcSetWebp":"/static/e4bc33e90fbf073c98a68bf53b1a8b87/61e93/791a9068fcdcdc7636ab94fbe31e8b00.webp 200w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/1f5c5/791a9068fcdcdc7636ab94fbe31e8b00.webp 400w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/58556/791a9068fcdcdc7636ab94fbe31e8b00.webp 800w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/99238/791a9068fcdcdc7636ab94fbe31e8b00.webp 1200w,\n/static/e4bc33e90fbf073c98a68bf53b1a8b87/91ab5/791a9068fcdcdc7636ab94fbe31e8b00.webp 1204w","sizes":"(max-width: 800px) 100vw, 800px"}}}}}]}},"pageContext":{"limit":12,"skip":0,"numPages":1,"currentPage":1,"id":5232,"name":"Endocannabinoids","slug":"endocannabinoids","country":"US"}},"staticQueryHashes":["3949754563","4179947113","4202924991"]}